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COVID-19 research

Gene: SCARB1

Amber List (moderate evidence)

SCARB1 (scavenger receptor class B member 1)
EnsemblGeneIds (GRCh38): ENSG00000073060
EnsemblGeneIds (GRCh37): ENSG00000073060
OMIM: 601040, Gene2Phenotype
SCARB1 is in 4 panels

1 review

Eleanor Williams (Genomics England Curator)

Comment on list classification: Rating Amber as there is some evidence that variants in this gene are associated with response to Hepatitus C virus
Created: 21 May 2020, 11:18 p.m. | Last Modified: 21 May 2020, 11:18 p.m.
Panel Version: 0.298
Not associated with any relevant disease phenotype in OMIM. SCARB1 is also known as SRB1

PMID: 12356718 - Scarselli et al 2002 - Characterization of hepatitis C virus (HCV) envelope glycoprotein E2 binding after chemical or enzymic modification of the cell surface led to the identification of the scavenger receptor type B class I (SR-BI) as the E2 receptor on HepG2 cells.

PMID: 28827115 - Sadeghi et al 2017 - SCARB1 rs10846744 (CC) genotype (P=0.001) was strongly associated with sustained virological response

PMID: 28363797 - Westhaus et al 2018 - Non-synonymous variants: S112F and T175A have greatly reduced Hepatitus C virus (HCV) receptor function. When present on the cell surface, these variants are impaired in their ability to interact with HCV E2. Non-coding variants: The G allele in rs3782287 is associated with decreased viral load.

PMID: 29715527 - Naffari et al 2018 -looked at treatment responses in 395 treatment-naïve patients with chronic Hepatitus C Virus (CHC) genotype 1 treated with pegylated interferon-α and ribavirin. Rapid virologic response (RVR), complete early virologic response (cEVR) , and sustained virologic responseSVR were significantly associated with SCARB1 rs10846744 (CC).
Sources: Literature
Created: 21 May 2020, 11:16 p.m.

Mode of inheritance



Mode of Inheritance
  • Expert Review Amber
  • Literature
Clinvar variants
Variants in SCARB1
Panels with this gene

History Filter Activity

21 May 2020, Gel status: 2

Entity classified by Genomics England curator

Eleanor Williams (Genomics England Curator)

Gene: scarb1 has been classified as Amber List (Moderate Evidence).

21 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Eleanor Williams (Genomics England Curator)

gene: SCARB1 was added gene: SCARB1 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: SCARB1 was set to Unknown