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COVID-19 research

Gene: IFNL4

Red List (low evidence)

IFNL4 (interferon lambda 4 (gene/pseudogene))
EnsemblGeneIds (GRCh38): ENSG00000272395
EnsemblGeneIds (GRCh37): ENSG00000272395
OMIM: 615090, Gene2Phenotype
IFNL4 is in 1 panel

1 review

Catherine Snow (Genomics England)

I don't know

IFNL4 was identified in preprint "A gene locus that controls expression of ACE2 in virus infection" A GWAS for performed for ACE2 expression in HCV-infected liver tissue from 195 individuals. it was discovered that polymorphisms in the host IFNL region which control expression of IFNL3 and IFNL4 modulate ACE2 expression.

PMID: 31776283 Investigates the IFNL4 gene - it acts in a counterintuitive manner, as patients with a nonfunctional IFNL4 gene exhibit increased clearance of hepatitis C virus (HCV) but also increased liver inflammation.
Sources: Literature
Created: 5 May 2020, 5:25 p.m. | Last Modified: 5 May 2020, 5:26 p.m.
Panel Version: 0.199

Mode of inheritance



Mode of Inheritance
  • Literature
Clinvar variants
Variants in IFNL4
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5 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Catherine Snow (Genomics England)

gene: IFNL4 was added gene: IFNL4 was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: IFNL4 was set to Unknown Publications for gene: IFNL4 were set to 31776283 Review for gene: IFNL4 was set to AMBER