COVID-19 research
Gene: FUT2
Mode of inheritance
Unknown
Publications
Comment on list classification: Variants in FUT2 are responsible for resistance to Norovirus infection in certain populations (PMID 30845670). This gene is Green on the Viral Resistance panel (https://panelapp.genomicsengland.co.uk/panels/928/gene/FUT2/#!review)Created: 15 Jun 2020, 11:59 a.m. | Last Modified: 15 Jun 2020, 11:59 a.m.
Panel Version: 1.50
FUT2 was identified through an OMIM search for potential viral susceptibility genes. Initial triage by Illumina (Alison Coffey and team) was given a Tier 3 grouping (experimental evidence and association data consistent with viral susceptibility). Illumina review: PMID: 30845670: Nordgren et al. (2019) (Review) The FUT2 gene encodes FUT2 enzyme, which catalyzes the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids, allowing the synthesis of histo-blood group antigens (HBGAs). The FUT2 gene is expressed predominately in epithelial (mucosal) tissues. Individuals with inactivated FUT2 enzyme, known as “non secretors” do not express blood group antigens in these tissues and are resistant to several norovirus genotypes. FUT2 polymorphisms with known effect on secretor status are present in different populations and are reviewed by Nordgren et al. (2019).
Created: 11 Jun 2020, 6:10 p.m. | Last Modified: 12 Jun 2020, 10:26 a.m.
Panel Version: 1.24
Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.Created: 2 Jun 2020, 1:53 p.m. | Last Modified: 2 Jun 2020, 1:53 p.m.
Panel Version: 1.1
Mode of inheritance for gene: FUT2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Gene: fut2 has been classified as Amber List (Moderate Evidence).
Publications for gene: FUT2 were set to 30845670
Publications for gene: FUT2 were set to
gene: FUT2 was added gene: FUT2 was added to COVID-19 research. Sources: OMIM,Expert list,Expert Review Amber Mode of inheritance for gene: FUT2 was set to Unknown Phenotypes for gene: FUT2 were set to {Norwalk virus infection, resistance to}