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COVID-19 research

Gene: FUT2

Amber List (moderate evidence)

FUT2 (fucosyltransferase 2)
EnsemblGeneIds (GRCh38): ENSG00000176920
EnsemblGeneIds (GRCh37): ENSG00000176920
OMIM: 182100, Gene2Phenotype
FUT2 is in 2 panels

3 reviews

Alison Coffey (Illumina Clinical Services Laboratory, Illumina Inc.)

Green List (high evidence)

Mode of inheritance
Unknown

Publications

Sarah Leigh (Genomics England Curator)

Comment on list classification: Variants in FUT2 are responsible for resistance to Norovirus infection in certain populations (PMID 30845670). This gene is Green on the Viral Resistance panel (https://panelapp.genomicsengland.co.uk/panels/928/gene/FUT2/#!review)
Created: 15 Jun 2020, 11:59 a.m. | Last Modified: 15 Jun 2020, 11:59 a.m.
Panel Version: 1.50
FUT2 was identified through an OMIM search for potential viral susceptibility genes. Initial triage by Illumina (Alison Coffey and team) was given a Tier 3 grouping (experimental evidence and association data consistent with viral susceptibility). Illumina review: PMID: 30845670: Nordgren et al. (2019) (Review) The FUT2 gene encodes FUT2 enzyme, which catalyzes the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids, allowing the synthesis of histo-blood group antigens (HBGAs). The FUT2 gene is expressed predominately in epithelial (mucosal) tissues. Individuals with inactivated FUT2 enzyme, known as “non secretors” do not express blood group antigens in these tissues and are resistant to several norovirus genotypes. FUT2 polymorphisms with known effect on secretor status are present in different populations and are reviewed by Nordgren et al. (2019).
Created: 11 Jun 2020, 6:10 p.m. | Last Modified: 12 Jun 2020, 10:26 a.m.
Panel Version: 1.24

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 2 Jun 2020, 1:53 p.m. | Last Modified: 2 Jun 2020, 1:53 p.m.
Panel Version: 1.1

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
Phenotypes
  • {Norwalk virus infection, resistance to}
OMIM
182100
Clinvar variants
Variants in FUT2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

15 Jun 2020, Gel status: 2

Set mode of inheritance

Sarah Leigh (Genomics England Curator)

Mode of inheritance for gene: FUT2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

15 Jun 2020, Gel status: 2

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: fut2 has been classified as Amber List (Moderate Evidence).

15 Jun 2020, Gel status: 2

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: FUT2 were set to 30845670

12 Jun 2020, Gel status: 2

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: FUT2 were set to

2 Jun 2020, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: FUT2 was added gene: FUT2 was added to COVID-19 research. Sources: OMIM,Expert list,Expert Review Amber Mode of inheritance for gene: FUT2 was set to Unknown Phenotypes for gene: FUT2 were set to {Norwalk virus infection, resistance to}