COVID-19 research
Gene: TNFSF4Comment on list classification: Not associated with relevant phenotype in OMIM or in Gen2Phen.Created: 28 May 2020, 5:07 p.m. | Last Modified: 28 May 2020, 5:07 p.m.
Panel Version: 0.362
TNFSF4 was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping).
Tumor necrosis factor (TNF) family cytokines function as prominent mediators of immune regulation and the inflammatory response. Most TNF family cytokines are expressed as type II transmembrane proteins, with homology confined to approximately 150 C-terminal residues. The TNF ligands interact with a parallel family of receptors (reviewed by Alison Coffey and team, Illumina).
TNFSF4 is a cell surface glycoprotein antigen that is expressed in T-cell leukemia virus type 1 (HTLV-1) infected human cells (PMID 7913952;8076595). Functional analysis showed that anti-TNFSF4 monoclonal antibody inhibited T-cell proliferation (PMID 11359859).
PMID 31725732: suggests that TNFSF4, one of the major causative cytokine factors in African swine fever virus pathogenesis, via inducing apoptosis.Created: 28 May 2020, 5:06 p.m. | Last Modified: 28 May 2020, 5:57 p.m.
Panel Version: 0.365
Publications for gene: TNFSF4 were set to 7913952; 8076595; 11359859
Gene: tnfsf4 has been classified as Red List (Low Evidence).
Publications for gene: TNFSF4 were set to 7913952; 8076595
Publications for gene: TNFSF4 were set to
gene: TNFSF4 was added gene: TNFSF4 was added to COVID-19 research. Sources: OMIM Mode of inheritance for gene: TNFSF4 was set to Unknown Phenotypes for gene: TNFSF4 were set to {Myocardial infarction, susceptibility to} 608446