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COVID-19 research

Gene: ACE

Red List (low evidence)

ACE (angiotensin I converting enzyme)
EnsemblGeneIds (GRCh38): ENSG00000159640
EnsemblGeneIds (GRCh37): ENSG00000159640
OMIM: 106180, Gene2Phenotype
ACE is in 11 panels

2 reviews

Abdelazeem Elhabyan (Arizona State University)

Red List (low evidence)

Ellen McDonagh (Genomics England Curator)

PMID: A case-control study found no association with the I/D polymorphism in this gene and increased susceptibility to SARS-coronavirus infection nor with poor outcomes after SARS-coronavirus infection (140 genetically unrelated Chinese SARS cases and 326 healthy volunteers were recruited).
Sources: Literature
Created: 30 Mar 2020, 4 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Not associated with susceptibility to SARS-coronavirus infection and disease outcomes

Publications

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
Phenotypes
  • Not associated with susceptibility to SARS-coronavirus infection and disease outcomes
OMIM
106180
Clinvar variants
Variants in ACE
Penetrance
None
Publications
Panels with this gene

History Filter Activity

2 Apr 2020, Gel status: 1

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: ace has been classified as Red List (Low Evidence).

30 Mar 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: ACE was added gene: ACE was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: ACE was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: ACE were set to 15819995 Phenotypes for gene: ACE were set to Not associated with susceptibility to SARS-coronavirus infection and disease outcomes