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COVID-19 research

Gene: CASP1

Green List (high evidence)

CASP1 (caspase 1)
EnsemblGeneIds (GRCh38): ENSG00000137752
EnsemblGeneIds (GRCh37): ENSG00000137752
OMIM: 147678, Gene2Phenotype
CASP1 is in 1 panel

2 reviews

Ivone Leong (Genomics England Curator)

Green List (high evidence)

PMID: 19362023 is a mouse study model where KO Casp1 mice were more susceptible than WT mice after infection with infleunza A. This increased morbidity was associated with decreased neutrophil and monocyte recruitment and reduced cytokine and chemokine production.

PMID: 32303424. CASP1 were Hub proteins in the regulating network of cytokine secretion suggesting that it is important in ACE2-associated inflammatory response in lungs.

Binding of COVID-19 to Toll-like receptors causes release of pro-IL-1b, which requires CASP1 to cleave it in order for inflammasome activation and production of mature IL-1b (mediator of lung inflammation, fever and fibrosis). Suppressing the IL-1 family and IL-6 has been shown to have a therapeutic effect in viral infections (PMID: 32171193). CASP1 has been suggested to be a potential target for treatment (PMID: 22432004).
Created: 28 May 2020, 12:51 p.m. | Last Modified: 28 May 2020, 12:51 p.m.
Panel Version: 0.336

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.
Panel Version: 0.336

Details

Mode of Inheritance
Unknown
Sources
OMIM
147678
Clinvar variants
Variants in CASP1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 3

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: CASP1 were set to

28 May 2020, Gel status: 3

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: CASP1 was added gene: CASP1 was added to COVID-19 research. Sources: Expert list,OMIM,Expert Review Green Mode of inheritance for gene: CASP1 was set to Unknown