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COVID-19 research

Gene: CNBP

Red List (low evidence)

CNBP (CCHC-type zinc finger nucleic acid binding protein)
EnsemblGeneIds (GRCh38): ENSG00000169714
EnsemblGeneIds (GRCh37): ENSG00000169714
OMIM: 116955, Gene2Phenotype
CNBP is in 9 panels

4 reviews

Arina Puzriakova (Genomics England Curator)

Comment on mode of inheritance: Lack of phenotypic relevance for SNVs - nucleotide repeat expansion mechanism
Created: 9 Nov 2021, 10:35 a.m. | Last Modified: 9 Nov 2021, 10:35 a.m.
Panel Version: 1.81

Rebecca Foulger (Genomics England curator)

The protein zinc finger repeats have sequence similarity to the finger domains of the family of retroviral nucleic acid-binding proteins (NBPs). No further publications supporting a link to viral infection susceptibility.
Created: 16 Apr 2020, 12:40 p.m. | Last Modified: 16 Apr 2020, 12:40 p.m.
Panel Version: 0.106

Sophie Hambleton (Newcastle University)

Red List (low evidence)

No evident link to immunodeficiency
Created: 11 Jun 2018, 4:14 p.m.

Louise Daugherty (Genomics England Curator)

I don't know

External expert review notes Red status due to no evident link to immunodeficiency, so I have kept this gene Red on this panel
Created: 12 Jun 2018, 12:27 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: ZNF9, PanelApp HGNC gene symbol check: CNBP, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Predominantly antibody disorders / Unclassified antibody deficiency / Steinert- myotonica dystrophia
Created: 17 Apr 2018, 12:29 p.m.


Mode of Inheritance
  • ESID Registry 20171117
  • Expert Review Red
  • Expert Review Red
  • ESID Registry 20171117
  • Myotonic dystrophy 2, OMIM:602668
  • Myotonic dystrophy type 2, MONDO:0011266
nucleotide-repeat-expansion currently-ngs-unreportable
Clinvar variants
Variants in CNBP
Panels with this gene

History Filter Activity

9 Nov 2021, Gel status: 1

Added Tag, Added Tag

Arina Puzriakova (Genomics England Curator)

Tag nucleotide-repeat-expansion tag was added to gene: CNBP. Tag currently-ngs-unreportable tag was added to gene: CNBP.

9 Nov 2021, Gel status: 1

Set mode of inheritance

Arina Puzriakova (Genomics England Curator)

Mode of inheritance for gene: CNBP was changed from Unknown to Other

24 Nov 2020, Gel status: 1

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: CNBP were changed from Steinert- myotonica dystrophia to Myotonic dystrophy 2, OMIM:602668; Myotonic dystrophy type 2, MONDO:0011266

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: CNBP was added gene: CNBP was added to Viral susceptibility. Sources: Expert Review Red,ESID Registry 20171117 Mode of inheritance for gene: CNBP was set to Unknown Phenotypes for gene: CNBP were set to Steinert- myotonica dystrophia