COVID-19 researchGene: CNBP
Comment on mode of inheritance: Lack of phenotypic relevance for SNVs - nucleotide repeat expansion mechanism
Created: 9 Nov 2021, 10:35 a.m. | Last Modified: 9 Nov 2021, 10:35 a.m.
Panel Version: 1.81
The protein zinc finger repeats have sequence similarity to the finger domains of the family of retroviral nucleic acid-binding proteins (NBPs). No further publications supporting a link to viral infection susceptibility.
Created: 16 Apr 2020, 12:40 p.m. | Last Modified: 16 Apr 2020, 12:40 p.m.
Panel Version: 0.106
No evident link to immunodeficiency
Created: 11 Jun 2018, 4:14 p.m.
External expert review notes Red status due to no evident link to immunodeficiency, so I have kept this gene Red on this panel
Created: 12 Jun 2018, 12:27 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: ZNF9, PanelApp HGNC gene symbol check: CNBP, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Predominantly antibody disorders / Unclassified antibody deficiency / Steinert- myotonica dystrophia
Created: 17 Apr 2018, 12:29 p.m.
Tag nucleotide-repeat-expansion tag was added to gene: CNBP. Tag currently-ngs-unreportable tag was added to gene: CNBP.
Mode of inheritance for gene: CNBP was changed from Unknown to Other
Phenotypes for gene: CNBP were changed from Steinert- myotonica dystrophia to Myotonic dystrophy 2, OMIM:602668; Myotonic dystrophy type 2, MONDO:0011266
gene: CNBP was added gene: CNBP was added to Viral susceptibility. Sources: Expert Review Red,ESID Registry 20171117 Mode of inheritance for gene: CNBP was set to Unknown Phenotypes for gene: CNBP were set to Steinert- myotonica dystrophia