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COVID-19 research

Gene: FCGR3B

Red List (low evidence)

FCGR3B (Fc fragment of IgG receptor IIIb)
EnsemblGeneIds (GRCh38): ENSG00000162747
EnsemblGeneIds (GRCh37): ENSG00000162747
OMIM: 610665, Gene2Phenotype
FCGR3B is in 5 panels

5 reviews

Catherine Snow (Genomics England)

Comment on list classification: Comment on list classification: No link to viral susceptibility some evidence of FCGR3B that variants give rise to susceptibility to develop auto-immune diseases including SLE (PMID: 26683154).
Created: 8 Apr 2020, 11:53 a.m. | Last Modified: 8 Apr 2020, 11:53 a.m.
Panel Version: 0.72

Louise Daugherty (Genomics England Curator)

I don't know

Comment on list classification: Changed from Amber to Red. Not strong PID, not an NK cell defect as it has been claimed
Created: 9 Jul 2018, 9:12 a.m.
This gene was present in the original PanelApp PID panel dataset (review in April 2018) rated as Red. The gene is present in the external expert immunodeficiency diagnostic gene list(s) GOSH or GRID. In this combined PID panel, this gene has been rated as AMBER and needs further curational review to assess pertinence prior to v1.
Created: 20 Apr 2018, 12:25 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: FCGR3B, PanelApp HGNC gene symbol check: FCGR3B, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Other well defined PIDs / Fc receptor deficiencies / Fc receptor deficiencies
Created: 17 Apr 2018, 12:29 p.m.
Original metadata supplied by GRID. GRID Gene Symbol HGNC PanelApp check: FCGR3B, GRID_Gene_Symbol: FCGR3B, GRID_Transcript_ENS_Community submitted: ENST00000531221, GRID_Transcript_RefSeq: NM_000570.4, GRID_Transcript_ENS_used_on_Production: ENST00000531221
Created: 17 Apr 2018, 12:12 p.m.

Tracy Briggs (Manchester Genomic Medicine Centre)

Red List (low evidence)

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Associated with Neutropenia, alloimmune neonatal on OMIM, no disease association on G2P, two expert reviewers suggest it as red and only found in 1/4 sources
Created: 24 May 2016, 8:14 p.m.

Sophie Hambleton (Newcastle University)

Red List (low evidence)

Maternal deficiency of the encoded protein can set the stage for transient neonatal isoimmune thrombocytopenia
Created: 19 Oct 2015, 10:41 p.m.



Mode of Inheritance
  • Expert Review Red
  • Congenital neutropaenia v1.22
  • GRID V2.0
  • ESID Registry 20171117
  • ESID Registry 20171117
  • GRID V2.0
  • Congenital neutropaenia v1.22
  • Neutropenia,alloimmuneneonatal
  • Neutropenia, autoimmune neonatal
  • Neutropenia, alloimmune neonatal
  • Fc receptor deficiencies
Clinvar variants
Variants in FCGR3B
Panels with this gene

History Filter Activity

8 Apr 2020, Gel status: 1

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: fcgr3b has been classified as Red List (Low Evidence).

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: FCGR3B was added gene: FCGR3B was added to Viral susceptibility. Sources: Expert Review Red,ESID Registry 20171117,GRID V2.0,Congenital neutropaenia v1.22 Mode of inheritance for gene: FCGR3B was set to Unknown Publications for gene: FCGR3B were set to 1978690 Phenotypes for gene: FCGR3B were set to Neutropenia,alloimmuneneonatal; Neutropenia, autoimmune neonatal; Neutropenia, alloimmune neonatal; Fc receptor deficiencies