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COVID-19 research

Gene: CTSL

Red List (low evidence)

CTSL (cathepsin L)
EnsemblGeneIds (GRCh38): ENSG00000135047
EnsemblGeneIds (GRCh37): ENSG00000135047
OMIM: 116880, Gene2Phenotype
CTSL is in 1 panel

2 reviews

Arina Puzriakova (Genomics England Curator)

I don't know

Preprint ( Genome-wide CRISPR screen showed CTSL was positively selected during SARS-CoV-2 infection, indicating this is a pro-viral gene and knockout confers resistance to virus-induced cell death.

CTSL encodes the Cathepsin L protease which mediates viral cell entry by cleaving the spike protein, in turn exposing the viral fusion peptide and enabling membrane fusion.

No variants have been described that modulate susceptibility to SARS-CoV-2; however, might be one to watch.
Created: 30 Jun 2020, 11:05 a.m. | Last Modified: 30 Jun 2020, 11:05 a.m.
Panel Version: 1.58

Mode of inheritance

Eleanor Williams (Genomics England Curator)

The Covid-19 cell atlas ( lists this gene as a COVID-19/SARS-CoV-2 entry-associated gene.
PMID: 32142651 - Hoffman et al 2020 - Cell journal - CatB/L involved in S protein priming.
Created: 26 Apr 2020, 2:43 p.m. | Last Modified: 26 Apr 2020, 3:03 p.m.
Panel Version: 0.163

Mode of inheritance


Mode of Inheritance
  • Other
Clinvar variants
Variants in CTSL
Panels with this gene

History Filter Activity

26 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Eleanor Williams (Genomics England Curator)

gene: CTSL was added gene: CTSL was added to Viral susceptibility. Sources: Other Mode of inheritance for gene: CTSL was set to Unknown