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COVID-19 research


Amber List (moderate evidence)

SERINC3 (serine incorporator 3)
EnsemblGeneIds (GRCh38): ENSG00000132824
EnsemblGeneIds (GRCh37): ENSG00000132824
OMIM: 607165, Gene2Phenotype
SERINC3 is in 1 panel

1 review

Catherine Snow (Genomics England)

I don't know

Curation by Illumina clinical curators contributing to Covid-19 effort. Curation on all OMIM genes which hit the term "virus".
No current gene disease relationship in OMIM.
The human immunodeficiency virus (HIV)-1 Nef protein and the unrelated murine leukemia virus (MLV) glycosylated Gag (glycoGag) protein enhance HIV-1 infectivity. Usami et al. (2015) found that silencing both SERINC3 and SERINC5 (614551) precisely phenocopied the effects of Nef and glycoGag on HIV-1 infectivity. CD4-positive T cells lacking both SERINC3 and SERINC5 showed significantly increased susceptibility to Nef-deficient virions. SERINC3 and SERINC5 together restricted HIV-1 replication, and this restriction was evaded by Nef. Usami et al. (2015) proposed that inhibiting Nef-mediated downregulation of SERINC3 and SERINC5, which are normally highly expressed in HIV-1 target cells, has the potential to combat HIV/AIDS.

Screening human cell lines and using CRISPR-Cas9 analysis, Rosa et al. (2015) found that SERINC5, and to a lesser extent SERINC3, inhibited infectivity of human immunodeficiency virus (HIV)-1 and murine leukemia retrovirus (MLV)
Sources: Literature
Created: 22 May 2020, 2:48 p.m. | Last Modified: 22 May 2020, 2:49 p.m.
Panel Version: 0.308

Mode of inheritance


Mode of Inheritance
  • Expert Review Amber
  • Literature
Clinvar variants
Variants in SERINC3
Panels with this gene

History Filter Activity

22 May 2020, Gel status: 2

Set publications

Catherine Snow (Genomics England)

Publications for gene: SERINC3 were set to

22 May 2020, Gel status: 2

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: serinc3 has been classified as Amber List (Moderate Evidence).

22 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Catherine Snow (Genomics England)

gene: SERINC3 was added gene: SERINC3 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: SERINC3 was set to Unknown Review for gene: SERINC3 was set to AMBER