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COVID-19 research

Gene: IL18

Amber List (moderate evidence)

IL18 (interleukin 18)
EnsemblGeneIds (GRCh38): ENSG00000150782
EnsemblGeneIds (GRCh37): ENSG00000150782
OMIM: 600953, Gene2Phenotype
IL18 is in 3 panels

3 reviews

Rebecca Foulger (Genomics England curator)

Comment on list classification: Updated rating from Red to Amber, based largely on PMID:31660404 who report identification of IL-18 polymorphisms that may confer a higher incidence of CMV infection (in kidney transplant patients). Additional expression assays studies in mice support a role for IL-18 in innate immunity viral response.
Created: 20 Apr 2020, 8:37 p.m. | Last Modified: 20 Apr 2020, 8:37 p.m.
Panel Version: 0.116
PMID:31660404. Perez-Flores examines two SNPs in the promoter region of IL-18 gene (-607C/A (rs1946518) and -137G/C (rs187238) in 498 adult kidney transplant recipients. Results suggest that the rs1946518/rs187238 haplotype is associated with a higher incidence of post-prophylaxis cytomegalovirus (CMV) infection. Prior identification of these SNPs could help select alternative measures to prevent delayed-onset CMV infection in these patients.
Created: 20 Apr 2020, 8:36 p.m. | Last Modified: 20 Apr 2020, 8:36 p.m.
Panel Version: 0.115
PMID:25395539 (Zhang et al 2014) report that IL-18 and IL-22 administration to mice offered protection against a broad range of RV inoculation, and may offer broad antiviral therapeutic potential.
Created: 20 Apr 2020, 8:31 p.m. | Last Modified: 20 Apr 2020, 8:39 p.m.
Panel Version: 0.118
PMID:15606801 (Van Der Sluijs et al., 2005): IL18 is upregulated in after Influenza infection, and IL18 deficiency is associated with accelerated viral clearance (mouse study).
Created: 20 Apr 2020, 8:24 p.m. | Last Modified: 20 Apr 2020, 8:26 p.m.
Panel Version: 0.113

Sophie Hambleton (Newcastle University)

I don't know

IL-18 is important in the pathogenesis of HLH (PMID:29326099) and the newly described autoinflammatory state IL18PAP-MAS (PMID: 31874111). Elevated IL-18 levels were detected in patients with COVID although not differentiating severe from mild/moderate disease (MedRxiv preprint https://doi.org/10.1101/2020.03.02.20029975). It is plausible that genetically determined differences in the activity of IL-18 might influence risk of severe COVID-19
Created: 7 May 2020, 4:38 p.m. | Last Modified: 7 May 2020, 4:38 p.m.
Panel Version: 0.204

Louise Daugherty (Genomics England Curator)

I don't know

External expert review notes Red status so I have kept this gene Red on this panel
Created: 12 Jun 2018, 4:42 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: IL18, PanelApp HGNC gene symbol check: IL18, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Phagocytic disorders / Defects with susceptibility to mycobacterial infection (MSMD) / Defects with susceptibility to mycobacterial infection (MSMD)
Created: 17 Apr 2018, 12:29 p.m.

Details

Mode of Inheritance
Unknown
Sources
Phenotypes
  • Defects with susceptibility to mycobacterial infection (MSMD)
OMIM
600953
Clinvar variants
Variants in IL18
Penetrance
None
Publications
Panels with this gene

History Filter Activity

20 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: il18 has been classified as Amber List (Moderate Evidence).

20 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: IL18 were set to 15606801; 25395539

20 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: IL18 were set to 15606801

20 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: IL18 were set to 15606801

20 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: IL18 were set to

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: IL18 was added gene: IL18 was added to Viral susceptibility. Sources: Expert Review Red,ESID Registry 20171117 Mode of inheritance for gene: IL18 was set to Unknown Phenotypes for gene: IL18 were set to Defects with susceptibility to mycobacterial infection (MSMD)