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COVID-19 research

Gene: IFNL3

Amber List (moderate evidence)

IFNL3 (interferon lambda 3)
EnsemblGeneIds (GRCh38): ENSG00000197110
EnsemblGeneIds (GRCh37): ENSG00000197110
OMIM: 607402, Gene2Phenotype
IFNL3 is in 1 panel

2 reviews

Sophie Hambleton (Newcastle University)

I don't know

GIven that innate interferons are involved in antiviral immunity within respiratory mucosa, you could argue they should be considered regardless of the fact that ACE2 is an interferon-stimulated gene. But I don't see the other innate interferons on this research panel besides IFNL3 - not convinced it has really earned special status!
Created: 7 May 2020, 4:17 p.m. | Last Modified: 7 May 2020, 4:17 p.m.
Panel Version: 0.204

Catherine Snow (Genomics England)

I don't know

IFNL3 was identified in preprint "A gene locus that controls expression of ACE2 in virus infection" A GWAS for performed for ACE2 expression in HCV-infected liver tissue from 195 individuals. it was discovered that polymorphisms in the host IFNL region which control expression of IFNL3 and IFNL4 modulate ACE2 expression.
Sources: Literature
Created: 5 May 2020, 5:40 p.m.

Mode of inheritance


Mode of Inheritance
  • Expert Review Amber
  • Literature
Clinvar variants
Variants in IFNL3
Panels with this gene

History Filter Activity

5 May 2020, Gel status: 2

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: ifnl3 has been classified as Amber List (Moderate Evidence).

5 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Catherine Snow (Genomics England)

gene: IFNL3 was added gene: IFNL3 was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: IFNL3 was set to Unknown Review for gene: IFNL3 was set to AMBER