COVID-19 research
Gene: ABO
Preprint (https://doi.org/10.1101/2020.06.13.20130211) authors identified the A blood group as a predictor of COVID-19 in patients who had undergone transcatheter aortic valve replacement - where it was shown to be significantly associated with disease severity and poor clinical outcome (hospitalisation and/or death). This finding is consistent with previous studies demonstrating an association between the A blood group and increased susceptibility to SARS-CoV-2 infection, whereas the O blood group appears to be protective.Created: 24 Jun 2020, 9:54 a.m. | Last Modified: 24 Jun 2020, 9:54 a.m.
Panel Version: 1.58
Mode of inheritance
Unknown
Phenotypes
Virus susceptibility
Preprint https://doi.org/10.1101/2020.06.07.20124610 Pourali et al 2020 - meta-analysis of blood group and risk of infect ion and death in COVID-19. Supports the finding that those with blood group A are at higher risk for COVID-19 infection while those with blood group O are at lower risk.Created: 16 Jun 2020, 4:46 p.m. | Last Modified: 16 Jun 2020, 4:46 p.m.
Panel Version: 1.58
Makes sense to evaluate influence of ABO as a potential susceptibility locusCreated: 7 May 2020, 4:09 p.m. | Last Modified: 7 May 2020, 4:09 p.m.
Panel Version: 0.204
Comment on list classification: Upgrade to Green based on expert reviewCreated: 12 May 2020, 8:39 a.m. | Last Modified: 12 May 2020, 8:39 a.m.
Panel Version: 0.208
Comment on list classification: Identified by expert review. Two preprints and publication relating to ABO and Sars-COV. https://doi.org/10.1101/2020.04.08.20058073 authors found that COVID-19 positive vs negative test results were increased in blood groups A and decreased in blood groups O, consistent with previous results from Wuhan and Shenzhen (https://doi.org/10.1101/2020.03.11.20031096)Created: 4 May 2020, 5:19 p.m. | Last Modified: 4 May 2020, 5:19 p.m.
Panel Version: 0.178
Preliminary suggestion from preprints (https://www.medrxiv.org/content/10.1101/2020.03.11.20031096v2 & https://www.preprints.org/manuscript/202003.0356/v1) that ABO blood group may influence susceptibility to SARS-CoV-2 infection. Other preliminary evidence that ABO blood group may also influence susceptibility to SARS-CoV infection (PMID: 15784866). Both yet to be replicated, but suggest individuals of blood group O to be at lower risk of infection.
Sources: LiteratureCreated: 25 Apr 2020, 7:43 a.m.
Mode of inheritance
Other
Publications
Mode of inheritance for gene: ABO was changed from Other to Unknown
Gene: abo has been classified as Green List (High Evidence).
Phenotypes for gene: ABO were changed from to Virus susceptibility
Gene: abo has been classified as Amber List (Moderate Evidence).
gene: ABO was added gene: ABO was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: ABO was set to Other Publications for gene: ABO were set to 15784866 Review for gene: ABO was set to AMBER