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STRs in panel
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COVID-19 research

Gene: ABCB1

Red List (low evidence)

ABCB1 (ATP binding cassette subfamily B member 1)
EnsemblGeneIds (GRCh38): ENSG00000085563
EnsemblGeneIds (GRCh37): ENSG00000085563
OMIM: 171050, Gene2Phenotype
ABCB1 is in 2 panels

2 reviews

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.
Panel Version: 0.336

Ivone Leong (Genomics England Curator)

Red List (low evidence)

Searching through PubMed, most of the papers related to ABCB1 are to do with drug efficacy and ABCB1's affect on HIV-1 treatments. Therefore, this gene should remain rated Red.
Created: 28 May 2020, 12:18 p.m. | Last Modified: 28 May 2020, 12:18 p.m.
Panel Version: 0.334
Comment on publications: PMID: 18547906 showed that ABCB1 SNP (C3435T) is associated with virological efficacy in treatments for HIV infected pateints.

PMID: 26922556 showed that SNPS in ABCB1 may influence HCV infectivity.
Created: 28 May 2020, 12:18 p.m. | Last Modified: 28 May 2020, 12:18 p.m.
Panel Version: 0.334

Details

Mode of Inheritance
Unknown
Sources
OMIM
171050
Clinvar variants
Variants in ABCB1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 1

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: ABCB1 were set to

28 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: ABCB1 was added gene: ABCB1 was added to COVID-19 research. Sources: Expert Review Red,OMIM,Expert list Mode of inheritance for gene: ABCB1 was set to Unknown