COVID-19 researchGene: ITGAM
CDIIB is a previous gene symbol for ITGAM. Expression evidence that ITGAM is involved in an immune response.
PMID: 29712964 An in vitro transepithelial migration assay to evaluate the role of neutrophils in Respiratory Syncytial Virus (RSV) induced epithelial damage. Neutrophils that migrated through the RSV infected airway epithelial cells (AECs) showed increased cell surface expression of CD11B and MPO compared to neutrophils that had not migrated.
PMID: 32257537 Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia. 7 enrolled patients were assessed for 14 days after MSC injection. After treatment, the peripheral lymphocytes were increased, the C-reactive protein decreased, and the overactivated cytokine-secreting immune cells CXCR3+CD4+ T cells, CXCR3+CD8+ T cells, and CXCR3+ NK cells disappeared in 3-6 days. In addition, a group of CD14+CD11c+CD11bmid regulatory DC cell population dramatically increased.
Although no specific gene disease evidence for ITGAM there is evidence that it is involved in the immune response and has been identified in a COVID-19 paper therefore classifying as Amber.
Created: 14 Apr 2020, 2:58 p.m. | Last Modified: 14 Apr 2020, 2:58 p.m.
Panel Version: 0.93
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Not associated with monogenic disease
Created: 20 Jun 2018, 7:52 p.m.
Comment on list classification: Changed from Amber to Red, no published cases of immunodeficiency to date. Red review from external expert review. Referred back to GRID and Victorian Clinical Genetics Services for evidences.
Created: 27 Jun 2018, 9:53 a.m.
This gene was absent from the original PanelApp PID panel dataset (review April 2018). However it was listed in external expert immunodeficiency diagnostic gene list(s) GOSH or GRID. In this combined PID panel, this gene has been rated as AMBER and needs further curational review to assess pertinence prior to v1.
Created: 20 Apr 2018, 12:25 p.m.
Original metadata supplied by GRID. GRID Gene Symbol HGNC PanelApp check: ITGAM, GRID_Gene_Symbol: ITGAM, GRID_Transcript_ENS_Community submitted: ENST00000544665, GRID_Transcript_RefSeq: NM_001145808.1, GRID_Transcript_ENS_used_on_Production: ENST00000544665
Created: 17 Apr 2018, 12:12 p.m.
Publications for gene: ITGAM were set to
Mode of inheritance for gene: ITGAM was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Gene: itgam has been classified as Amber List (Moderate Evidence).
gene: ITGAM was added gene: ITGAM was added to Viral susceptibility. Sources: Expert Review Red,Victorian Clinical Genetics Services,GRID V2.0 Mode of inheritance for gene: ITGAM was set to Unknown Phenotypes for gene: ITGAM were set to Systemic lupus erythematous