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COVID-19 research

Gene: FCGR2B

Red List (low evidence)

FCGR2B (Fc fragment of IgG receptor IIb)
EnsemblGeneIds (GRCh38): ENSG00000072694
EnsemblGeneIds (GRCh37): ENSG00000072694
OMIM: 604590, Gene2Phenotype
FCGR2B is in 2 panels

3 reviews

Catherine Snow (Genomics England)

Comment on list classification: No link to viral susceptibility some evidence of FCGR2B that variants give rise to susceptibility to develop auto-immune diseases (PMID: 26683154)
Created: 8 Apr 2020, 11:42 a.m. | Last Modified: 8 Apr 2020, 11:52 a.m.
Panel Version: 0.71

Sophie Hambleton (Newcastle University)

Red List (low evidence)

No link to Mendelian immune disorder
Created: 11 Jun 2018, 2:27 p.m.

Louise Daugherty (Genomics England Curator)

I don't know

External expert review notes Red status due to no evident link to Mendelian immunodeficiency, so I have kept this gene Red on this panel
Created: 12 Jun 2018, 1:01 p.m.
External expert review notes Red status due to no evident link to Mendelian immunodeficiency, so I have kept this gene Red on this panel
Created: 12 Jun 2018, 12:51 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: FCGR2B, PanelApp HGNC gene symbol check: FCGR2B, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Other well defined PIDs / Fc receptor deficiencies / Fc receptor deficiencies
Created: 17 Apr 2018, 12:29 p.m.

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
Phenotypes
  • Fc receptor deficiencies
OMIM
604590
Clinvar variants
Variants in FCGR2B
Penetrance
None
Panels with this gene

History Filter Activity

8 Apr 2020, Gel status: 1

Entity classified by Genomics England curator

Catherine Snow (Genomics England)

Gene: fcgr2b has been classified as Red List (Low Evidence).

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: FCGR2B was added gene: FCGR2B was added to Viral susceptibility. Sources: Expert Review Red,ESID Registry 20171117 Mode of inheritance for gene: FCGR2B was set to Unknown Phenotypes for gene: FCGR2B were set to Fc receptor deficiencies