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COVID-19 research

Gene: SOCS1

Red List (low evidence)

SOCS1 (suppressor of cytokine signaling 1)
EnsemblGeneIds (GRCh38): ENSG00000185338
EnsemblGeneIds (GRCh37): ENSG00000185338
OMIM: 603597, Gene2Phenotype
SOCS1 is in 1 panel

1 review

Sarah Leigh (Genomics England Curator)

I don't know

PMID 12588885: In coxsackievirus-infected mice cardiac myocyte-specific transgenic expression of SOCS1 inhibited virus-induced signaling of JAK and STAT resulting in increased viral replication, cardiomyopathy, and mortality compared to controls. Inhibition of SOCS in cardiac myocytes increased myocyte resistance to the acute cardiac injury of enteroviral infection. It was suggested that inhibition of SOCS could augment the host-cell antiviral system and might prevent viral-mediated end-organ damage during the early stages of infection.
https://doi.org/10.1101/499988 reports: Genome-wide association study to identify loci that are associated with PID, and found evidence for the colocalization of—and interplay between—novel high-penetrance monogenic variants and common variants (at the PTPN2 and SOCS1 loci).

Sources: Literature
Created: 19 May 2020, 2:01 p.m. | Last Modified: 19 May 2020, 2:03 p.m.
Panel Version: 0.243

Mode of inheritance
Unknown

Phenotypes
primary immunodeficiency

Publications

Details

Mode of Inheritance
Unknown
Sources
  • Literature
Phenotypes
  • primary immunodeficiency
OMIM
603597
Clinvar variants
Variants in SOCS1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

19 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Sarah Leigh (Genomics England Curator)

gene: SOCS1 was added gene: SOCS1 was added to COVID-19 research. Sources: Literature Mode of inheritance for gene: SOCS1 was set to Unknown Publications for gene: SOCS1 were set to 12588885; 12588885; 18172216 Phenotypes for gene: SOCS1 were set to primary immunodeficiency Review for gene: SOCS1 was set to AMBER