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COVID-19 research

Gene: CD4

Amber List (moderate evidence)

CD4 (CD4 molecule)
EnsemblGeneIds (GRCh38): ENSG00000010610
EnsemblGeneIds (GRCh37): ENSG00000010610
OMIM: 186940, Gene2Phenotype
CD4 is in 3 panels

4 reviews

Ivone Leong (Genomics England Curator)

Comment on list classification: Promoted from Red to Amber based on expert review.

"Single individual reported, functional data, emerging gene.
Zornitza Stark (Australian Genomics), 1 May 2020" - review copied from Primary immunodeficiency (Version 2.155).
Created: 5 May 2020, 3:16 p.m. | Last Modified: 5 May 2020, 3:16 p.m.
Panel Version: 0.195

Rebecca Foulger (Genomics England curator)

PMID:25611551 (Lu et al., 2015) reports no association between the CD4 C868T polymorphism and an individual's susceptibility of HIV-1 in a Chinese population.
Created: 14 Apr 2020, 3:53 p.m. | Last Modified: 14 Apr 2020, 3:53 p.m.
Panel Version: 0.98

Sophie Hambleton (Newcastle University)

Red List (low evidence)

Louise Daugherty (Genomics England Curator)

I don't know

External expert review notes Red status due to no evident link to immunodeficiency, so I have kept this gene Red on this panel
Created: 12 Jun 2018, 3:32 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: CD4, PanelApp HGNC gene symbol check: CD4, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Combined immunodeficiencies / CD4-deficiency / Selective CD4 cell deficiency
Created: 17 Apr 2018, 12:29 p.m.

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
Phenotypes
  • Selective CD4 cell deficiency
  • OKT4 epitope deficiency, 613949
  • Absence of CD4+ T cells
  • exuberant, relapsing, treatment-refractory warts
OMIM
186940
Clinvar variants
Variants in CD4
Penetrance
None
Publications
Panels with this gene

History Filter Activity

5 May 2020, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: cd4 has been classified as Amber List (Moderate Evidence).

5 May 2020, Gel status: 1

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: CD4 were changed from Selective CD4 cell deficiency to Selective CD4 cell deficiency; OKT4 epitope deficiency, 613949; Absence of CD4+ T cells; exuberant, relapsing, treatment-refractory warts

5 May 2020, Gel status: 1

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: CD4 were set to 25611551

5 May 2020, Gel status: 1

Set mode of inheritance

Ivone Leong (Genomics England Curator)

Mode of inheritance for gene: CD4 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

14 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: CD4 were set to

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: CD4 was added gene: CD4 was added to Viral susceptibility. Sources: Expert Review Red,ESID Registry 20171117 Mode of inheritance for gene: CD4 was set to Unknown Phenotypes for gene: CD4 were set to Selective CD4 cell deficiency