COVID-19 researchGene: CD4
Comment on list classification: Promoted from Red to Amber based on expert review.
"Single individual reported, functional data, emerging gene.
Zornitza Stark (Australian Genomics), 1 May 2020" - review copied from Primary immunodeficiency (Version 2.155).
Created: 5 May 2020, 3:16 p.m. | Last Modified: 5 May 2020, 3:16 p.m.
Panel Version: 0.195
PMID:25611551 (Lu et al., 2015) reports no association between the CD4 C868T polymorphism and an individual's susceptibility of HIV-1 in a Chinese population.
Created: 14 Apr 2020, 3:53 p.m. | Last Modified: 14 Apr 2020, 3:53 p.m.
Panel Version: 0.98
External expert review notes Red status due to no evident link to immunodeficiency, so I have kept this gene Red on this panel
Created: 12 Jun 2018, 3:32 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: CD4, PanelApp HGNC gene symbol check: CD4, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Combined immunodeficiencies / CD4-deficiency / Selective CD4 cell deficiency
Created: 17 Apr 2018, 12:29 p.m.
Gene: cd4 has been classified as Amber List (Moderate Evidence).
Phenotypes for gene: CD4 were changed from Selective CD4 cell deficiency to Selective CD4 cell deficiency; OKT4 epitope deficiency, 613949; Absence of CD4+ T cells; exuberant, relapsing, treatment-refractory warts
Publications for gene: CD4 were set to 25611551
Mode of inheritance for gene: CD4 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: CD4 were set to
gene: CD4 was added gene: CD4 was added to Viral susceptibility. Sources: Expert Review Red,ESID Registry 20171117 Mode of inheritance for gene: CD4 was set to Unknown Phenotypes for gene: CD4 were set to Selective CD4 cell deficiency