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COVID-19 research

Gene: APOE

Amber List (moderate evidence)

APOE (apolipoprotein E)
EnsemblGeneIds (GRCh38): ENSG00000130203
EnsemblGeneIds (GRCh37): ENSG00000130203
OMIM: 107741, Gene2Phenotype
APOE is in 9 panels

1 review

Eleanor Williams (Genomics England Curator)

Comment on list classification: Rating amber as one study reported showing that a variant (ApoE e4 allele) is associated with hospitalization with COVID-19.
Created: 13 May 2020, 1:38 p.m. | Last Modified: 13 May 2020, 1:38 p.m.
Panel Version: 0.225
PMID: 32451547 - Kuo et al 2020 - Using UK biobank data they found that the ApoE e4 allele ( rs429358) increases risks of being hospitalized with COVID-19, independent of pre-existing dementia, cardiovascular disease, and type-2 diabetes. ApoE e4e4 homozygotes were more likely to be COVID-19 test positives compared to e3e3 homozygotes. ApoE e4 allele frequency is higher in people of African ancestry than in Europeans, and preliminary results suggest that ApoE e4 prevalence makes a modest contribution to the excess incidence of COVID-19 in Blacks. (Originially added to the panel as preprint: https://doi.org/10.1101/2020.05.07.20094409)
Sources: Literature

Created: 13 May 2020, 1:36 p.m. | Last Modified: 26 May 2020, 3:57 p.m.
Panel Version: 0.327

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
dementia

Publications

  • https://doi.org/10.1101/2020.05.07.20094409

History Filter Activity

26 May 2020, Gel status: 2

Set publications

Eleanor Williams (Genomics England Curator)

Publications for gene: APOE were set to https://doi.org/10.1101/2020.05.07.20094409

13 May 2020, Gel status: 2

Entity classified by Genomics England curator

Eleanor Williams (Genomics England Curator)

Gene: apoe has been classified as Amber List (Moderate Evidence).

13 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Eleanor Williams (Genomics England Curator)

gene: APOE was added gene: APOE was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: APOE was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: APOE were set to https://doi.org/10.1101/2020.05.07.20094409 Phenotypes for gene: APOE were set to dementia