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COVID-19 research

Gene: CLDN6

Red List (low evidence)

CLDN6 (claudin 6)
EnsemblGeneIds (GRCh38): ENSG00000184697
EnsemblGeneIds (GRCh37): ENSG00000184697
OMIM: 615798, Gene2Phenotype
CLDN6 is in 1 panel

2 reviews

Alison Coffey (Illumina Clinical Services Laboratory, Illumina Inc.)

Red List (low evidence)

Evidence Summary from Illumina curation team: CLDN6 gene encodes the Claudin-6 protein. The claudin family constitutes of a large group of four- transmembrane domain proteins that are essential for the formation of tight junctions responsible for the control of paracellular transport. Studies have demonstrated that CLDN6 and CLDN9 mediate the entry of the Hepatitis C virus (HCV) into both liver and non-liver cells (Zheng et al. 2007) however, HCV infection is not dependent on the presence of CLDN6 (Haid et al. 2014; Fofana et al. 2013).
Created: 28 May 2020, 3:12 p.m. | Last Modified: 28 May 2020, 3:12 p.m.
Panel Version: 0.347

Publications

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.
Panel Version: 0.336

Details

Mode of Inheritance
Unknown
Sources
OMIM
615798
Clinvar variants
Variants in CLDN6
Penetrance
None
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: CLDN6 was added gene: CLDN6 was added to COVID-19 research. Sources: Expert Review Red,OMIM,Expert list Mode of inheritance for gene: CLDN6 was set to Unknown