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COVID-19 research

Gene: CCL11

Red List (low evidence)

CCL11 (C-C motif chemokine ligand 11)
EnsemblGeneIds (GRCh38): ENSG00000172156
EnsemblGeneIds (GRCh37): ENSG00000172156
OMIM: 601156, Gene2Phenotype
CCL11 is in 2 panels

2 reviews

Alison Coffey (Illumina Clinical Services Laboratory, Illumina Inc.)

I don't know

Mode of inheritance


Sarah Leigh (Genomics England Curator)

CCL11 was identified through an OMIM search for potential viral susceptibility genes. Initial triage by Illumina (Alison Coffey and team) was given a Tier 3 grouping (experimental evidence and association data consistent with viral susceptibility). Illumina review: CCL11 is a cytokine released in response to viral infections. No evidence found of SNPs in association with SARS-CoV-2 infection. From OMIM: PMID: 14571188: Modi et al. (2003) identified 3 SNPs that formed a 31-kb haplotype (H7) spanning the CCL2-CCL7-CCL11 gene cluster on chromosome 17q. The SNPs and the H7 haplotype were significantly associated with protection from HIV-1 infection. PMID:30915442: Hoffman et al. (2019) - West Nile virus infection outcome vary among individuals with most infections resulting in asymptomatic or mild-flu like symptoms. WNV-infected females reported more symptoms than males. Males were shown to exibit a protracted cytokine response including CCL11 (and CCL2, CXCL10 and IL-15) that was absent in females. PMID:32416070: Blanco-Melo et al. (2020) - look at the transcriptional response to SARS-CoV-2 compared to other respiratory viruses. Cell and animal models of SARS-CoV-2 infection, in addition to transcriptional and serum profiling of COVID-19 patients, consistently revealed a unique and inappropriate inflammatory response. This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. SARS-CoV-2 shown to induce robust levels of chemokines including CCL2, CCl8 and CCL11 (Figure 4A).
Created: 11 Jun 2020, 6:10 p.m. | Last Modified: 12 Jun 2020, 9:58 a.m.
Panel Version: 1.12
Comment on list classification: A cytokine (inflammatory biomarker), that is released in response to viral infections. Increased levels of CCL11 amongst other cytokines, is associated with immunity to West Nile virus (PMID 30915442). A haplotype that included c.-1385G>A was associated with resistance to HIV-1 infection (PMID 14571188).
Created: 23 Apr 2020, 5:56 p.m. | Last Modified: 23 Apr 2020, 5:56 p.m.
Panel Version: 0.155


  • Expert Review Red
  • OMIM
Clinvar variants
Variants in CCL11
Panels with this gene

History Filter Activity

12 Jun 2020, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: CCL11 were set to 14571188; 30915442

23 Apr 2020, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: CCL11 were set to

23 Apr 2020, Gel status: 1

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: ccl11 has been classified as Red List (Low Evidence).

21 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: CCL11 was added gene: CCL11 was added to Viral susceptibility. Sources: OMIM Mode of inheritance for gene: CCL11 was set to