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COVID-19 research

Gene: HIVEP1

Red List (low evidence)

HIVEP1 (human immunodeficiency virus type I enhancer binding protein 1)
EnsemblGeneIds (GRCh38): ENSG00000095951
EnsemblGeneIds (GRCh37): ENSG00000095951
OMIM: 194540, Gene2Phenotype
HIVEP1 is in 1 panel

1 review

Rebecca Foulger (Genomics England curator)

Comment on list classification: HIVEP1 was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping) and additional curation, added to panel as Red. Not yet associated with an OMIM disorder. No direct evidence for a role in viral infection, but binds a DNA sequence that is common in the enhancer elements of numerous viral promoters including simian virus 40, cytomegalovirus and HIV.
Created: 21 May 2020, 2:41 p.m. | Last Modified: 21 May 2020, 2:41 p.m.
Panel Version: 0.263
Comment on publications: Note that PMID:24719322 (Modulation of TLR3, TLR4 and TLR7 Mediated IFN-β, Rantes and TNFα Production by HIVEP1) was withdrawn by the author.
Created: 21 May 2020, 2:39 p.m. | Last Modified: 21 May 2020, 2:39 p.m.
Panel Version: 0.262
Notes from Julie Taylor and Alison Coffey (Illumina): Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV).
Created: 21 May 2020, 10:43 a.m. | Last Modified: 21 May 2020, 10:43 a.m.
Panel Version: 0.261

Details

Mode of Inheritance
Unknown
Sources
OMIM
194540
Clinvar variants
Variants in HIVEP1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

21 May 2020, Gel status: 1

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: hivep1 has been classified as Red List (Low Evidence).

21 May 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: HIVEP1 were set to

21 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: HIVEP1 was added gene: HIVEP1 was added to COVID-19 research. Sources: Other Mode of inheritance for gene: HIVEP1 was set to Unknown