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COVID-19 research

Gene: FCMR

Amber List (moderate evidence)

FCMR (Fc fragment of IgM receptor)
EnsemblGeneIds (GRCh38): ENSG00000162894
EnsemblGeneIds (GRCh37): ENSG00000162894
OMIM: 606015, Gene2Phenotype
FCMR is in 1 panel

2 reviews

Catherine Snow (Genomics England)

Immunoglobulin (Ig) M plays an important role in immune regulation. FCMR-encoded FcμR is a receptor of IgM. Chang et al (PMID:32073687) explored the roles of mRNA expressions of IgM receptors, particularly FCMR, in Kawasaki disease patients.
PMID:29461978 demonstrate that in mice the specific deletion of fcmr on B cells results in impaired antiviral T cell responses.
Created: 28 May 2020, 4:11 p.m. | Last Modified: 28 May 2020, 4:11 p.m.
Panel Version: 0.353

Publications

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team. Listed under gene symbol FAIM3 in OMIM.
Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.
Panel Version: 0.336

Details

Mode of Inheritance
Unknown
Sources
OMIM
606015
Clinvar variants
Variants in FCMR
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 2

Set publications

Catherine Snow (Genomics England)

Publications for gene: FCMR were set to

28 May 2020, Gel status: 2

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: FCMR was added gene: FCMR was added to COVID-19 research. Sources: Expert list,OMIM,Expert Review Amber Mode of inheritance for gene: FCMR was set to Unknown