COVID-19 researchGene: CD200
Comment on list classification: Not associated with a phenotype in OMIM or in Gen2Phen. However, CD200 is a membrane protein that interacts with CD200R on the surface of immune cells and delivers an inhibitory signal to suppress immune functions as a "check point" to prevent an excessive inflammatory response . Viral homologs of CD200, such as rat cytomegalovirus e127 protein, may play a role in suppressing the host immune response (PMID 19587022).
Conversely, in coronavirus infection, inhibition of CD200-CD200R1 results in restoring IFN production and increasing virus clearance (PMID 30032349).
Therefore understanding of the mechanisms of CD200-CD200R action may help in development of treatments.
Created: 29 May 2020, 10:31 a.m. | Last Modified: 29 May 2020, 10:31 a.m.
Panel Version: 0.376
CD200 was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping).
Rygiel et al. (2009)(PMID 19587022) found that Cd200 -/- mice challenged with influenza virus developed more severe disease, which was associated with increased lung infiltration and lung endothelium damage, compared with wildtype controls. Cd200 -/- mice did develop immune responses that could control viral load, suggesting that the severe disease was caused by an exaggerated immune response. Disease could be prevented by T-cell depletion before viral challenge, despite the dramatically increased viral load that resulted. Rygiel et al. (2009) concluded that T cells are essential for the manifestation of disease symptoms during influenza infection, and that lack of downmodulating CD200-CD200R signaling, rather than viral load, increases immune pathology (reviewed by Alison Coffey and team, Illumina).
Created: 29 May 2020, 9:31 a.m. | Last Modified: 29 May 2020, 9:31 a.m.
Panel Version: 0.374
Publications for gene: CD200 were set to 19587022
Gene: cd200 has been classified as Red List (Low Evidence).
Publications for gene: CD200 were set to
gene: CD200 was added gene: CD200 was added to COVID-19 research. Sources: OMIM Mode of inheritance for gene: CD200 was set to Unknown