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COVID-19 research

Gene: FEZ1

Amber List (moderate evidence)

FEZ1 (fasciculation and elongation protein zeta 1)
EnsemblGeneIds (GRCh38): ENSG00000149557
EnsemblGeneIds (GRCh37): ENSG00000149557
OMIM: 604825, Gene2Phenotype
FEZ1 is in 1 panel

2 reviews

Catherine Snow (Genomics England)

Huang et al. PMID:31422020 find that the viral cofactor FEZ1, a kinesin adaptor protein, uses multiple negatively charged amino-acid stretches to avidly interact with the positive center pores of the HIV-1 capsid protein hexamers, associating the virus particles to kinesin motors and thus promoting viral trafficking and infection.
Created: 28 May 2020, 4:54 p.m. | Last Modified: 28 May 2020, 4:54 p.m.
Panel Version: 0.360

Publications

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.
Panel Version: 0.336

Details

Mode of Inheritance
Unknown
Sources
OMIM
604825
Clinvar variants
Variants in FEZ1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 2

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: FEZ1 were set to

28 May 2020, Gel status: 2

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: FEZ1 was added gene: FEZ1 was added to COVID-19 research. Sources: Expert list,OMIM,Expert Review Amber Mode of inheritance for gene: FEZ1 was set to Unknown