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COVID-19 research

Gene: VPS33A

Red List (low evidence)

VPS33A (VPS33A, CORVET/HOPS core subunit)
EnsemblGeneIds (GRCh38): ENSG00000139719
EnsemblGeneIds (GRCh37): ENSG00000139719
OMIM: 610034, Gene2Phenotype
VPS33A is in 1 panel

2 reviews

Alison Coffey (Illumina Clinical Services Laboratory, Illumina Inc.)

Red List (low evidence)

Evidence Summary from Illumina curation team: VPS33A is a member of the Sec1/Munc18-related (SM) protein family and a core component of the class C core vacuole/endosome tethering (CORVET) and the homotypic fusion and protein sorting (HOPS) complexes (Vasilev et al. 2020). Both complexes are heterohexamers and share four subunits. VPS33A, VPS11, VPS16 and VPS18, involved in endolysosomal pathway. Deficiency of VPS33A was shown to affect susceptibility to certain viruses in cell culture, including Ebola and Marburg viruses (Carette et al. 2011), however no human studies confirming this association were identified.
Created: 28 May 2020, 3:12 p.m. | Last Modified: 28 May 2020, 3:12 p.m.
Panel Version: 0.347

Publications

Rebecca Foulger (Genomics England curator)

Identified through an OMIM search for potential viral susceptibility genes, and subsequently triaged/reviewed by Illumina curation team.
Created: 28 May 2020, 12:36 p.m. | Last Modified: 28 May 2020, 12:36 p.m.
Panel Version: 0.336

Details

Mode of Inheritance
Unknown
Sources
OMIM
610034
Clinvar variants
Variants in VPS33A
Penetrance
None
Panels with this gene

History Filter Activity

28 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Rebecca Foulger (Genomics England curator)

gene: VPS33A was added gene: VPS33A was added to COVID-19 research. Sources: Expert Review Red,OMIM,Expert list Mode of inheritance for gene: VPS33A was set to Unknown