Genes in panel
STRs in panel
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COVID-19 research

Gene: IL23A

Red List (low evidence)

IL23A (interleukin 23 subunit alpha)
EnsemblGeneIds (GRCh38): ENSG00000110944
EnsemblGeneIds (GRCh37): ENSG00000110944
OMIM: 605580, Gene2Phenotype
IL23A is in 2 panels

3 reviews

Rebecca Foulger (Genomics England curator)

PMID:19200759 report a mouse model where IL-23 p19 (Il23a(-/-)) mice have increased susceptibility to lethal WNV encephalitis.
Created: 23 Apr 2020, 3:52 p.m. | Last Modified: 23 Apr 2020, 3:52 p.m.
Panel Version: 0.145

Sophie Hambleton (Newcastle University)

Red List (low evidence)

Louise Daugherty (Genomics England Curator)

I don't know

External expert review notes Red status, so I have kept this gene Red on this panel
Created: 12 Jun 2018, 4:42 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: IL23-alpha, PanelApp HGNC gene symbol check: IL23A, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Phagocytic disorders / Defects with susceptibility to mycobacterial infection (MSMD) / Defects with susceptibility to mycobacterial infection (MSMD)
Created: 17 Apr 2018, 12:29 p.m.

Details

Mode of Inheritance
Unknown
Sources
Phenotypes
  • Defects with susceptibility to mycobacterial infection (MSMD)
OMIM
605580
Clinvar variants
Variants in IL23A
Penetrance
None
Publications
Panels with this gene

History Filter Activity

23 Apr 2020, Gel status: 1

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: IL23A were set to

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: IL23A was added gene: IL23A was added to Viral susceptibility. Sources: Expert Review Red,ESID Registry 20171117 Mode of inheritance for gene: IL23A was set to Unknown Phenotypes for gene: IL23A were set to Defects with susceptibility to mycobacterial infection (MSMD)