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COVID-19 research

Gene: VPS4A

Red List (low evidence)

VPS4A (vacuolar protein sorting 4 homolog A)
EnsemblGeneIds (GRCh38): ENSG00000132612
EnsemblGeneIds (GRCh37): ENSG00000132612
OMIM: 609982, Gene2Phenotype
VPS4A is in 5 panels

1 review

Sarah Leigh (Genomics England Curator)

VPS4A was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping).

"VPS4 ATPases recognize their CHMP substrates to facilitate the membrane fission events required for the release of viruses, endosomal vesicles, and daughter cell VPS4A belongs to the AAA (ATPases associated with diverse cellular activities) protein family and is involved in lysosomal/endosomal membrane trafficking" (reviewed by Alison Coffey and team, Illumina).
In the review article PMID 30615963, it sets out how in late-stage infection with HIV, the Endosomal Sorting Complex Required for Transport (ESCRT) complexes and Vps4 are recruited to the plasma membrane where they enable the budding of the HIV particles and Ebola (another enveloped virus). In conclusion, they discuss agents that target host proteins such as Vps4p and ESCRT-III as antivirals.
Created: 28 May 2020, 7:55 p.m. | Last Modified: 28 May 2020, 7:55 p.m.
Panel Version: 0.368



History Filter Activity

28 May 2020, Gel status: 1

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: VPS4A were set to

28 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: VPS4A was added gene: VPS4A was added to COVID-19 research. Sources: OMIM Mode of inheritance for gene: VPS4A was set to Unknown