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COVID-19 research

Gene: KPNA2

Red List (low evidence)

KPNA2 (karyopherin subunit alpha 2)
EnsemblGeneIds (GRCh38): ENSG00000182481
EnsemblGeneIds (GRCh37): ENSG00000182481
OMIM: 600685, Gene2Phenotype
KPNA2 is in 1 panel

1 review

Rebecca Foulger (Genomics England curator)

Comment on list classification: Added KPNA2 to the panel as a Red gene. Present in the latest UniProt COVID portal release based on functional data that show an interaction with SARS-COVID viral ORF6 protein.
Created: 12 May 2020, 10:18 a.m. | Last Modified: 12 May 2020, 10:18 a.m.
Panel Version: 0.214
KPNA2 is present in the UniProt COVID portal (11th May 2020 Release): KPNA2 acts as a nuclear import factor. KPNA2 is retained in ER/Golgi membranes upon interaction with SARS-COV virus ORF6 protein, and therefore KPNA2 is unable to transport STAT1 into the nucleus, therby blocking the expression of STAT1-activated genes that establish an antiviral state (PMID:17596301).
Sources: Literature, Other
Created: 12 May 2020, 10:17 a.m. | Last Modified: 12 May 2020, 10:18 a.m.
Panel Version: 0.213

Mode of inheritance



Mode of Inheritance
  • Expert Review Red
  • Other
  • Literature
Clinvar variants
Variants in KPNA2
Panels with this gene

History Filter Activity

12 May 2020, Gel status: 1

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: kpna2 has been classified as Red List (Low Evidence).

12 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Rebecca Foulger (Genomics England curator)

gene: KPNA2 was added gene: KPNA2 was added to Viral susceptibility. Sources: Literature,Other Mode of inheritance for gene: KPNA2 was set to Unknown Publications for gene: KPNA2 were set to 17596301