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COVID-19 research

Gene: KPNA2

Red List (low evidence)

KPNA2 (karyopherin subunit alpha 2)
EnsemblGeneIds (GRCh38): ENSG00000182481
EnsemblGeneIds (GRCh37): ENSG00000182481
OMIM: 600685, Gene2Phenotype
KPNA2 is in 1 panel

1 review

Rebecca Foulger (Genomics England curator)

Comment on list classification: Added KPNA2 to the panel as a Red gene. Present in the latest UniProt COVID portal release based on functional data that show an interaction with SARS-COVID viral ORF6 protein.
Created: 12 May 2020, 10:18 a.m. | Last Modified: 12 May 2020, 10:18 a.m.
Panel Version: 0.214
KPNA2 is present in the UniProt COVID portal (11th May 2020 Release): https://covid-19.uniprot.org/uniprotkb/P52292. KPNA2 acts as a nuclear import factor. KPNA2 is retained in ER/Golgi membranes upon interaction with SARS-COV virus ORF6 protein, and therefore KPNA2 is unable to transport STAT1 into the nucleus, therby blocking the expression of STAT1-activated genes that establish an antiviral state (PMID:17596301).
Sources: Literature, Other
Created: 12 May 2020, 10:17 a.m. | Last Modified: 12 May 2020, 10:18 a.m.
Panel Version: 0.213

Mode of inheritance
Unknown

Publications

Details

Mode of Inheritance
Unknown
Sources
OMIM
600685
Clinvar variants
Variants in KPNA2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

12 May 2020, Gel status: 1

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: kpna2 has been classified as Red List (Low Evidence).

12 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Rebecca Foulger (Genomics England curator)

gene: KPNA2 was added gene: KPNA2 was added to Viral susceptibility. Sources: Literature,Other Mode of inheritance for gene: KPNA2 was set to Unknown Publications for gene: KPNA2 were set to 17596301