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COVID-19 research

Gene: KRT18

Red List (low evidence)

KRT18 (keratin 18)
EnsemblGeneIds (GRCh38): ENSG00000111057
EnsemblGeneIds (GRCh37): ENSG00000111057
OMIM: 148070, Gene2Phenotype
KRT18 is in 1 panel

1 review

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

Mouse model with variant krt18 are susceptibile to hepatotoxitiy after administering certain drugs. In PMID 8770877, the authors suggest that susceptibility to hepatotoxitiy upon exposure to environmental factor such as a virus or hepatotoxin is due to the effects of variants in krt18.
Created: 4 May 2020, 3:17 p.m. | Last Modified: 4 May 2020, 3:17 p.m.
Panel Version: 0.176

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

{Cirrhosis, noncryptogenic, susceptibility to} 215600; Cirrhosis, cryptogenic 215600



  • OMIM
Clinvar variants
Variants in KRT18
Panels with this gene

History Filter Activity

21 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: KRT18 was added gene: KRT18 was added to Viral susceptibility. Sources: OMIM Mode of inheritance for gene: KRT18 was set to