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COVID-19 research

Gene: UNC5CL

Red List (low evidence)

UNC5CL (unc-5 family C-terminal like)
EnsemblGeneIds (GRCh38): ENSG00000124602
EnsemblGeneIds (GRCh37): ENSG00000124602
OMIM: 617464, Gene2Phenotype
UNC5CL is in 1 panel

1 review

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

Using Collaborative Cross mouse genetic reference population, PMID 32348764 studied the genetic regulation of variation in antibody response to influenza A virus (IAV) infection. This enabled the identification of 23 quantitative trait loci (QTL) associated with variation in specific antibody isotypes across time points; this allowed a subset to be found that broadly affect the antibody response to IAV as well as other viruses. This gene is the equivalent human for the mouse gene that was classified as a candidate from one of the QTLs, based on the predicted variant consequences and haplotype-specific expression patterns (PMID 32348764 table 2).
Created: 27 May 2020, 10:50 a.m. | Last Modified: 27 May 2020, 10:50 a.m.
Panel Version: 0.332

Mode of inheritance

Influenza A Virus-Specific Antibody Responses



  • Literature
Clinvar variants
Variants in UNC5CL
Panels with this gene

History Filter Activity

5 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Sarah Leigh (Genomics England Curator)

gene: UNC5CL was added gene: UNC5CL was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: UNC5CL was set to