COVID-19 researchGene: ICOSLG
Not associated with phenotype in OMIM or in Gen2Phen. One homozygous variant reported in one case of Combined Immunodeficiency. Supportive functional evidence was presented. This variant in this French Canadian case has been reported twice in PMID 30498080 & 31532372.
Created: 7 May 2020, 2:22 p.m. | Last Modified: 7 May 2020, 2:22 p.m.
Panel Version: 0.203
Variants in this gene might be predicted to cause immunodeficiency but monogenic deficiency has not so far been described in humans, to my knowledge
Created: 29 Jun 2018, 2:13 p.m.
Added publication referenced by IUIS december 2019 update
Created: 28 Feb 2020, 8:49 p.m. | Last Modified: 28 Feb 2020, 8:49 p.m.
Panel Version: 2.36
Comment on list classification: Changed from Amber to Red due to Red review from external expert. To be referred back to Victorian Clinical Genetics Services for evidences for monogenic deficiency. Gene absent on other PID panels and is not known gene on IUIS and ESID classifications.
Created: 4 Jul 2018, 10:24 a.m.
Comment on list classification: This gene was absent from the original PanelApp PID panel dataset (review April 2018). However it was listed in external expert immunodeficiency diagnostic gene list from Victorian Clinical Genetics Services. In this combined PID panel, this gene has been rated as AMBER and needs further curational review to assess pertinence prior to v1. No disorder or MOI was listed in the submitted list.
Created: 26 Jun 2018, 12:46 p.m.
Source Expert Review Green was added to ICOSLG. Added phenotypes Immunodeficiencies affecting cellular and humoral immunity; Recurrent bacterial and viral infections for gene: ICOSLG Rating Changed from Red List (low evidence) to Green List (high evidence)
gene: ICOSLG was added gene: ICOSLG was added to Viral susceptibility. Sources: Expert Review Red,Victorian Clinical Genetics Services,IUIS Classification December 2019 Mode of inheritance for gene: ICOSLG was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: ICOSLG were set to 32086639; 32048120; 30498080 Phenotypes for gene: ICOSLG were set to Immunodeficiencies affecting cellular and humoral immunity; Recurrent bacterial and viral infections