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COVID-19 research

Gene: MX1

Red List (low evidence)

MX1 (MX dynamin like GTPase 1)
EnsemblGeneIds (GRCh38): ENSG00000157601
EnsemblGeneIds (GRCh37): ENSG00000157601
OMIM: 147150, Gene2Phenotype
MX1 is in 2 panels

1 review

Sarah Leigh (Genomics England Curator)

I don't know

MX1 is an interferon-induced protein with antiviral activity (PMID 3162334).
PMID 14872030 c.-88G>T was more frequent in 40 unrelated Japanese patients with subacute sclerosing panencephalitisis (associated with CNS infection with measles virus), than in 90 controls (0.42 in patients vs 0.29 in controls). Variant c.-88G>T results increased MX1 expression, the authors suggest that MX1 may paradoxically enable persistence of the virus in the CNS by attenuating viral gene expression and preventing complete immunologic clearance.
PMID 21935451 concluded that genetic variation in the interferon response pathway is associated with risk for symptomatic West Nile viru infection and disease progression.
Preprint Reports that rs35074065 of TMPRSS2 results in increased expression of the nearby gene MX1.
Sources: Literature
Created: 12 May 2020, 10:59 a.m.

Mode of inheritance



Mode of Inheritance
  • Literature
Clinvar variants
Variants in MX1
Panels with this gene

History Filter Activity

12 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Sarah Leigh (Genomics England Curator)

gene: MX1 was added gene: MX1 was added to Viral susceptibility. Sources: Literature Mode of inheritance for gene: MX1 was set to Unknown Publications for gene: MX1 were set to 3162334; 14872030; 21935451; Review for gene: MX1 was set to AMBER