COVID-19 researchGene: MTOR
Comment on list classification: A number of papers provide evidence that some viruses use mTOR signaling to promote their replication (e.g. PMID:28953980), and how inhibition of PI3K/TOR signaling inhibits viral replication (e.g. PMID:29475942). No variant studies on TOR so Red rating appropriate for now.
Created: 21 May 2020, 9:02 p.m. | Last Modified: 21 May 2020, 9:02 p.m.
Panel Version: 0.290
PMID:19543266. Araki et al. (2009) demonstrated that mTOR is a major regulator of memory CD8 T-cell differentiation. Treatment of mice with rapamycin following acute lymphocytic choriomeningitis virus infection enhanced the quantity and quality of virus-specific CD8 T cells. Rapamycin treatment also enhanced memory T-cell responses in nonhuman primates following vaccination with modified vaccinia virus Ankara.
Created: 21 May 2020, 9 p.m. | Last Modified: 21 May 2020, 9 p.m.
Panel Version: 0.289
MTOR was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping) and additional curation, added to panel as Red. Notes from Julie Taylor and Alison Coffey (Illumina): mTOR is a major regulator of memory CD8 T-cell differentiation.
Created: 21 May 2020, 9 p.m.
Mode of inheritance
Gene: mtor has been classified as Red List (Low Evidence).
Phenotypes for gene: MTOR were changed from 19543266 to 19543266; 29475942; 28953980
gene: MTOR was added gene: MTOR was added to COVID-19 research. Sources: Other Mode of inheritance for gene: MTOR was set to Unknown Phenotypes for gene: MTOR were set to 19543266