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COVID-19 research

Gene: IGHG2

Red List (low evidence)

IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker))
EnsemblGeneIds (GRCh38): ENSG00000211893
EnsemblGeneIds (GRCh37): ENSG00000211893
OMIM: 147110, Gene2Phenotype
IGHG2 is in 2 panels

3 reviews

Ivone Leong (Genomics England Curator)

PMID: 16092453 found that homozygous IGHG2(-n/-n) genotypes are associated with the development of severe respiratory syncytial virus (RSV) lower respiratory tract infection. IGHG2(-n/-n) genotype was more prevalent in hospitalized children with severe RSV infection (55.1% compared with 34.2% in healthy population (OR 2.3; p = 0.004)).
Created: 7 Apr 2020, 10:17 a.m. | Last Modified: 7 Apr 2020, 10:17 a.m.
Panel Version: 0.59


Sophie Hambleton (Newcastle University)

Red List (low evidence)

Louise Daugherty (Genomics England Curator)

I don't know

External expert review notes Red status so I have kept this gene Red on this panel
Created: 12 Jun 2018, 4:41 p.m.
Original metadata downloaded from ESID Registry. ESID_Gene_original: Heavy chain, PanelApp HGNC gene symbol check: IGHG2, ESID classification: Main_category/ Sub_category/ PID_Diagnosis Predominantly antibody disorders / Hypogammaglobulinemias / Immunoglobulin chain deficiencies
Created: 17 Apr 2018, 12:29 p.m.


Mode of Inheritance
  • ESID Registry 20171117
  • Expert Review Red
  • Expert Review Red
  • ESID Registry 20171117
  • Immunoglobulin chain deficiencies
Clinvar variants
Variants in IGHG2
Panels with this gene

History Filter Activity

1 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: IGHG2 was added gene: IGHG2 was added to Viral susceptibility. Sources: Expert Review Red,ESID Registry 20171117 Mode of inheritance for gene: IGHG2 was set to Unknown Phenotypes for gene: IGHG2 were set to Immunoglobulin chain deficiencies