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COVID-19 research

Gene: LILRB1

Amber List (moderate evidence)

LILRB1 (leukocyte immunoglobulin like receptor B1)
EnsemblGeneIds (GRCh38): ENSG00000104972
EnsemblGeneIds (GRCh37): ENSG00000104972
OMIM: 604811, Gene2Phenotype
LILRB1 is in 1 panel

1 review

Rebecca Foulger (Genomics England curator)

PMID:29528338. Davidson et al., 2018 tested whether LILRB1 genotype influences HCMV susceptibility by analysing LILRB1 genotypes (5 SNPs) in a group of 67 Canadian transplant patients. There was no association between LILRB1 SNPs and virus replication within the entire STCS population, but when the analyses were restricted to kidney transplant recipients, a significant association of rs10423364 was found with HCMV infection.
Created: 21 May 2020, 3:27 p.m. | Last Modified: 21 May 2020, 3:27 p.m.
Panel Version: 0.267
PMID:32321755. Yu et al., 2020 studied a polymorphic 3-kb region within LILRB1 intron 1 that binds the transcription factor YY1 to regulate LILRB1 levels.
Created: 21 May 2020, 3:27 p.m. | Last Modified: 21 May 2020, 3:27 p.m.
Panel Version: 0.267
PMID:30461037. Cadena-Mota et al., 2018 show that cytomegalovirus infection has a major effect on LILRB1 expression in NK and other mononuclear cells, and polymorphisms in the LILRB1 regulatory region appear to have a modulatory influence over this effect.
Created: 21 May 2020, 3:27 p.m. | Last Modified: 21 May 2020, 3:27 p.m.
Panel Version: 0.267
Comment on list classification: HIVEP1 was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping) and additional curation, added to panel as Amber. PMID:29528338 study investigates LILRB1 genotype and viral susceptibility and finds an association within transplant patients (but not within the population as a whole).
Created: 21 May 2020, 3:27 p.m. | Last Modified: 21 May 2020, 3:27 p.m.
Panel Version: 0.267
Notes from Julie Taylor and Alison Coffey (Illumina): Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells.
Created: 21 May 2020, 3:26 p.m. | Last Modified: 21 May 2020, 3:26 p.m.
Panel Version: 0.266

Details

Mode of Inheritance
Unknown
Sources
Phenotypes
  • HCMV susceptibility
OMIM
604811
Clinvar variants
Variants in LILRB1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

21 May 2020, Gel status: 2

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: lilrb1 has been classified as Amber List (Moderate Evidence).

21 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: LILRB1 was added gene: LILRB1 was added to COVID-19 research. Sources: Other Mode of inheritance for gene: LILRB1 was set to Unknown Publications for gene: LILRB1 were set to 30461037; 32321755; 29528338 Phenotypes for gene: LILRB1 were set to HCMV susceptibility