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COVID-19 research v0.287 MST1R Rebecca Foulger Classified gene: MST1R as Red List (low evidence)
COVID-19 research v0.287 MST1R Rebecca Foulger Added comment: Comment on list classification: Kept rating as Red for now: Possible involvement in viral-induced carcinomas, but most evidence for a role in the viral life cycle comes from animal models.
COVID-19 research v0.287 MST1R Rebecca Foulger Gene: mst1r has been classified as Red List (Low Evidence).
COVID-19 research v0.286 MST1R Rebecca Foulger Added comment: Comment on publications: Note that in the literature, MST1R is often referred to as RON for the human and Stk for the rodent orthologs.
COVID-19 research v0.286 MST1R Rebecca Foulger Publications for gene: MST1R were set to 15557181; 22974584; 16527351
COVID-19 research v0.285 MST1R Rebecca Foulger commented on gene: MST1R: PMID:22974584 Chou et al., 2012 demonstrate involvement of MST1R (RON) in Epstein-Barr virus (EBV)-associated Nasopharyngeal carcinoma (NPC).
COVID-19 research v0.285 MST1R Rebecca Foulger commented on gene: MST1R: PMID:15557181. Lee et al. (2004) proposed that HIV-1 may directly or indirectly target MST1R (RON) to disrupt normal signals that actively suppress inflammation to assure a microenvironment favorable for virus replication.
COVID-19 research v0.285 MST1R Rebecca Foulger Publications for gene: MST1R were set to
COVID-19 research v0.284 MST1R Rebecca Foulger gene: MST1R was added
gene: MST1R was added to COVID-19 research. Sources: Other
Mode of inheritance for gene: MST1R was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes for gene: MST1R were set to {Nasopharyngeal carcinoma, susceptibility to, 3}, 617075
Added comment: MST1R was identified through an OMIM search for potential viral susceptibility genes. Based on initial triage by Illumina (Tier 5 grouping) and additional curation, added to panel as Red.
Sources: Other