SLX4

SLX4 structure-specific endonuclease subunit
OMIM: 613278, Gene2Phenotype

18 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 18 panels
Green SLX4 in Radial dysplasia Level 3: Dysmorphic disorders Level 2: Dysmorphic and congenital abnormality syndromes Version 1.25	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Expert list Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen UKGTN Eligibility statement prior genetic testing Phenotypes Fanconi anemia, complementation group P, 613951
Green SLX4 in Haematological malignancies for rare disease Level 3: Tumour syndromes Level 2: Tumour syndromes Version 1.19	review	BIALLELIC, autosomal or pseudoautosomal	Sources Curated sources Expert Review Green Phenotypes Class: BM failure FA, (typ AR) Fanconi anemia MDS AML Bone marrow failure Head and neck and anogenital squamous cell cancers, liver cancer, esophageal cancer, Squamous cell carcinoma: oral, GI, vulvar
Green SLX4 in Head and neck cancer pertinent cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.1	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Expert list Phenotypes Class: BM failure FA, (typ AR) Fanconi anemia MDS AML Bone marrow failure Head and neck and anogenital squamous cell cancers, liver cancer, esophageal cancer, Squamous cell carcinoma: oral, GI, vulvar
Green SLX4 in Neurofibromatosis Type 1 Level 3: Muscle and nerve Level 2: Tumour syndromes Version 1.33	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green UKGTN Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services Phenotypes Fanconi anemia, complementation group P, 613951 Fanconi Anemia Fanconi Anaemia
Green SLX4 in COVID-19 research Level 2: Viral research Version 1.147	review	BIALLELIC, autosomal or pseudoautosomal	Sources IUIS Classification December 2019 Expert Review Green Phenotypes Fanconi anemia, complementation group P, 613951
Green SLX4 in Childhood solid tumours Level 2: Cancer susceptibility Version 5.10 Latest signed off version: v5.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources NHS GMS Expert List Expert Review Green UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Phenotypes Fanconi Anaemia Fanconi anemia, complementation group P, 613951 Fanconi Anemia
Green SLX4 in Limb disorders Level 2: Musculoskeletal Version 7.25 Latest signed off version: v7.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Victorian Clinical Genetics Services Phenotypes Fanconi anemia, complementation group P, 613951 Radial Ray abnormality
Green SLX4 in Pigmentary skin disorders Level 2: Dermatology Version 4.13 Latest signed off version: v4.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources London North GLH NHS GMS Expert Review Green Phenotypes Fanconi Anaemia FANCP FANCONI ANEMIA, COMPLEMENTATION GROUP P
Green SLX4 in Cytopenias and congenital anaemias Level 3: Anaemias and red cell disorders Level 2: Haematological disorders Version 1.124	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Illumina TruGenome Clinical Sequencing Services UKGTN Expert list Phenotypes Fanconi Anemia Fanconi anemia, complementation group P, 613951
Amber SLX4 in Childhood solid tumours cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.30	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber Phenotypes Fanconi anemia, complementation group P, 613951
Amber SLX4 in Adult solid tumours cancer susceptibility Level 2: Cancer susceptibility Version 2.35 Latest signed off version: v2.2 (18 Feb 2020)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Amber NHS GMS Phenotypes Fanconi anemia, complementation group P, 613951
Green SLX4 in Haematological malignancies cancer susceptibility Level 2: Cancer susceptibility Version 4.40 Latest signed off version: v4.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Curated sources Phenotypes Class: BM failure FA, (typ AR) Fanconi anemia MDS AML Bone marrow failure Head and neck and anogenital squamous cell cancers, liver cancer, esophageal cancer, Squamous cell carcinoma: oral, GI, vulvar
Green SLX4 in Severe microcephaly Level 2: Neurology Version 8.43 Latest signed off version: v8.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Green Other Phenotypes Fanconi anemia, complementation group P, 613951 (Microcephaly)
Green SLX4 in Confirmed Fanconi anaemia or Bloom syndrome Level 2: Haematology Version 2.13 Latest signed off version: v2.5 (1 May 2024)	review	BIALLELIC, autosomal or pseudoautosomal	Sources North West GLH Yorkshire and North East GLH NHS GMS Expert Review Green Wessex and West Midlands GLH Phenotypes Fanconi Anemia 613951 Fanconi Anemia Fanconi anemia, complementation group P Fanconi anemia, complementation group P, 613951
Green SLX4 in Fetal anomalies Level 2: Fetal (including NIPD) Version 6.185 Latest signed off version: v6.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources PAGE DD-Gene2Phenotype Expert Review Green Phenotypes FANCONI ANEMIA COMPLEMENTATION GROUP P
Green SLX4 in DDG2P Version 6.447 Latest signed off version: v6.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources DD-Gene2Phenotype Expert Review Green Phenotypes FANCONI ANEMIA COMPLEMENTATION GROUP P 613951
Green SLX4 in Intellectual disability Level 2: Developmental disorders Version 9.370 Latest signed off version: v9.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources Victorian Clinical Genetics Services Expert Review Green Phenotypes FANCONI ANEMIA COMPLEMENTATION GROUP P
Green SLX4 in Monogenic short stature Level 2: Endocrinology Version 1.31 Latest signed off version: v1.0 (7 Aug 2024)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Phenotypes Fanconi anemia, complementation group P, OMIM:613951