Head and neck cancer pertinent cancer susceptibility

Gene: SLX4

Green List (high evidence)

SLX4 (SLX4 structure-specific endonuclease subunit)
EnsemblGeneIds (GRCh38): ENSG00000188827
EnsemblGeneIds (GRCh37): ENSG00000188827
OMIM: 613278, Gene2Phenotype
SLX4 is in 17 panels

1 review

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Promoted to Green for inclusion in the germline pipeline for head and neck cancer.
Created: 20 Aug 2018, 1:22 p.m.
This gene was suggested by Lara Hawkes (Cancer Clinical Team, Genomics England) to be added to this panel, from the Haematological malignancies pertinent cancer susceptibility gene panel.
Created: 20 Aug 2018, 1:21 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Class: BM failure FA, (typ AR); Fanconi anemia; MDS; AML; Bone marrow failure; Head and neck and anogenital squamous cell cancers, liver cancer, esophageal cancer, Squamous cell carcinoma: oral, GI, vulvar

Publications

History Filter Activity

7 Sep 2018, Gel status: 3

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Ellen McDonagh: This gene was suggested by Lar

20 Aug 2018, Gel status: 3

Entity classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

Gene: slx4 has been classified as Green List (High Evidence).

20 Aug 2018, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

SLX4 was added to Head and neck cancer pertinent cancer susceptibility panel. Sources: Expert list

20 Aug 2018, Gel status: 1

Created

Ellen McDonagh (Genomics England Curator)

SLX4 was created by Ellen McDonagh