Head and neck cancer pertinent cancer susceptibility

Gene: FANCB

Green List (high evidence)

FANCB (Fanconi anemia complementation group B)
EnsemblGeneIds (GRCh38): ENSG00000181544
EnsemblGeneIds (GRCh37): ENSG00000181544
OMIM: 300515, Gene2Phenotype
FANCB is in 22 panels

3 reviews

Louise Daugherty (Genomics England Curator)

Comment on mode of inheritance: Changed to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males).- the gene is encoded on chromosome Xp22.2
Created: 25 Sep 2017, 1:24 p.m.
Comment on publications: added publication to support change in MOI
Created: 25 Sep 2017, 11:59 a.m.

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Details checked against the original gene list from Clare Turnbull.
Created: 26 Jul 2017, 11:18 a.m.

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Head and neck cancer

History Filter Activity

7 Sep 2018, Gel status: 3

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Ellen McDonagh: Comment on list classification

25 Sep 2017, Gel status: 4

Set Mode of Inheritance

Louise Daugherty (Genomics England Curator)

Mode of inheritance for FANCB was changed to X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

25 Sep 2017, Gel status: 4

Set publications

Louise Daugherty (Genomics England Curator)

Publications for FANCB were set to 21910217

26 Jul 2017, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

19 Jul 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

FANCB was added to Head and neck cancerpanel. Sources: Expert list

19 Jul 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

FANCB was created by ellenmcdonagh