FBXW7

F-box and WD repeat domain containing 7
OMIM: 606278, Gene2Phenotype

5 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 5 panels
Amber FBXW7 in Childhood solid tumours Level 2: Cancer susceptibility Version 5.12 Latest signed off version: v5.11 (6 May 2026)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Amber Literature Phenotypes Wilms tumor, MONDO:0006058 Rhabdoid tumor, MONDO:0002728 Tags watchlist
Red FBXW7 in Cytopenias and congenital anaemias Level 3: Anaemias and red cell disorders Level 2: Haematological disorders Version 1.124	review	Unknown	Sources Expert Review Red BRIDGE consortium (NIHRBR-RD) Phenotypes Acute lymphoblastic leukemia (ALL) Tags somatic
Green FBXW7 in Fetal anomalies Level 2: Fetal (including NIPD) Version 7.7 Latest signed off version: v7.0 (6 May 2026)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Phenotypes Developmental delay, hypotonia, and impaired language, OMIM:620012
Green FBXW7 in DDG2P Version 7.1 Latest signed off version: v7.0 (6 May 2026) Component of the following Super Panels: Paediatric disorders	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources DD-Gene2Phenotype Expert Review Green Phenotypes FBXW7-related developmental disorder (monoallelic)
Green FBXW7 in Intellectual disability Level 2: Developmental disorders Version 10.16 Latest signed off version: v10.0 (6 May 2026) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green NHS GMS Literature Phenotypes Developmental delay, hypotonia, and impaired language, OMIM:620012