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Cytopenias and congenital anaemias

Gene: FBXW7

Red List (low evidence)

FBXW7 (F-box and WD repeat domain containing 7)
EnsemblGeneIds (GRCh38): ENSG00000109670
EnsemblGeneIds (GRCh37): ENSG00000109670
OMIM: 606278, Gene2Phenotype
FBXW7 is in 1 panel

2 reviews

Ellen McDonagh (Genomics England Curator)

Comment on list classification: The COSMIC census gene list indicates that variants are somatic for colorectal, endometrial and T-cell acute lymphoblastic leukaemia. Information on OMIM indicates that somatic variants have been identified in cancer cell lines. Not associated with a disorder in OMIM or Gene2Phenotype. Literature search confirmed this is a somatic gene.
Created: 7 Mar 2017, 3:18 p.m.

BRIDGE consortium (NIHRBR-RD)

Green List (high evidence)

Mode of inheritance
Unknown

Phenotypes
Acute lymphoblastic leukemia (ALL)

Variants in this GENE are reported as part of current diagnostic practice

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • BRIDGE consortium (NIHRBR-RD)
Phenotypes
  • Acute lymphoblastic leukemia (ALL)
Tags
somatic
OMIM
606278
Clinvar variants
Variants in FBXW7
Penetrance
Complete
Mode of Pathogenicity
Other - please provide details in the comments
Panels with this gene

History Filter Activity

11 Mar 2017, Gel status: 1

panel promoted to version 1

Arianna Tucci (Genomics England Curator)

Promoted to V1 on 11 March 2017, after internal review and discussion with the clinical team.

7 Mar 2017, Gel status: 1

Set mode of pathogenicity

Ellen McDonagh (Genomics England Curator)

Mode of pathogenicity for FBXW7 was changed to Other - please provide details in the comments

7 Mar 2017, Gel status: 1

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

7 Mar 2017, Gel status: 1

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

17 Feb 2017, Gel status: 0

Created

Louise Daugherty (Genomics England Curator)

FBXW7 was created by LouiseD

17 Feb 2017, Gel status: 0

Added New Source

Louise Daugherty (Genomics England Curator)

FBXW7 was added to Cytopaenias and congenital anaemiaspanel. Sources: BRIDGE consortium (NIHRBR-RD)