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Cytopenias and congenital anaemias

Gene: TET2

Red List (low evidence)

TET2 (tet methylcytosine dioxygenase 2)
EnsemblGeneIds (GRCh38): ENSG00000168769
EnsemblGeneIds (GRCh37): ENSG00000168769
OMIM: 612839, Gene2Phenotype
TET2 is in 2 panels

2 reviews

Helen Brittain (Genomics England Curator)

Red List (low evidence)

Somatic. Mutations associated with MDS and myeloid tumorigenesis
Created: 9 Mar 2017, 4:32 p.m.

Mode of inheritance
Other - please specify in evaluation comments

Phenotypes
Myelodysplastic syndrome, somatic, 614286

BRIDGE consortium (NIHRBR-RD)

Green List (high evidence)

Mode of inheritance
Unknown

Phenotypes
Myelodysplastic syndrome (MDS), Paediatric

Variants in this GENE are reported as part of current diagnostic practice

Details

Mode of Inheritance
Other - please specify in evaluation comments
Sources
  • Expert Review Red
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Myelodysplastic syndrome, somatic, 614286
Tags
somatic
OMIM
612839
Clinvar variants
Variants in TET2
Penetrance
Complete
Panels with this gene

History Filter Activity

11 Mar 2017, Gel status: 1

panel promoted to version 1

Arianna Tucci (Genomics England Curator)

Promoted to V1 on 11 March 2017, after internal review and discussion with the clinical team.

9 Mar 2017, Gel status: 1

Set Mode of Inheritance, Added New Source

Sarah Leigh (Genomics England Curator)

TET2 was added to Cytopaenias and congenital anaemiaspanel. Source: Expert Review Red Model of inheritance for gene TET2 was set to Other - please specify in evaluation comments

17 Feb 2017, Gel status: 0

Created

Louise Daugherty (Genomics England Curator)

TET2 was created by LouiseD

17 Feb 2017, Gel status: 1

Added New Source

Louise Daugherty (Genomics England Curator)

TET2 was added to Cytopaenias and congenital anaemiaspanel. Sources: Radboud University Medical Center, Nijmegen