Cytopenias and congenital anaemias
Gene: DNMT3AComment on list classification: Somatic variants are associated with aplastic anaemia, as indicated by COSMIC census gene list and PMID: 28107566.Created: 1 Mar 2017, 2:25 p.m.
Mode of inheritance
Unknown
Phenotypes
Myelodysplastic syndrome (MDS), Paediatric
Variants in this GENE are reported as part of current diagnostic practice
Promoted to V1 on 11 March 2017, after internal review and discussion with the clinical team.
Phenotypes for DNMT3A were set to Myelodysplastic syndrome (MDS), Paediatric; acute myeloid leukaemia; aquired aplastic anaemia
Phenotypes for DNMT3A were set to Myelodysplastic syndrome (MDS), Paediatric; aplastic anaemia; acute myeloid leukaemia;aquired aplastic anaemia
This gene has been classified as Red List (Low Evidence).
Phenotypes for DNMT3A were set to Myelodysplastic syndrome (MDS), Paediatric; aplastic anaemia;acute myeloid leukaemia
Phenotypes for DNMT3A were set to Myelodysplastic syndrome (MDS), Paediatric;aplastic anaemia
This gene has been classified as Red List (Low Evidence).
DNMT3A was added to Cytopaenias and congenital anaemiaspanel. Sources: BRIDGE consortium (NIHRBR-RD)
DNMT3A was created by LouiseD