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  2. Cytopenias and congenital anaemias
  3. CD59
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Cytopenias and congenital anaemias

Gene: CD59

Green List (high evidence)
CD59 (CD59 molecule (CD59 blood group))
EnsemblGeneIds (GRCh38): ENSG00000085063
EnsemblGeneIds (GRCh37): ENSG00000085063
OMIM: 107271, Gene2Phenotype
CD59 is in 6 panels

1 review

Rebecca Foulger (Genomics England curator)

Comment when marking as ready: Relevant phenotype for panel and 3 cases to support causation.
Created: 9 Mar 2017, 10:49 a.m.
Comment on mode of inheritance: Mode of inheritance confirmed by OMIM.
Created: 9 Mar 2017, 10:48 a.m.
Comment on list classification: Updated rating from Green to Red: 3 cases in multiple populations supporting CD59-mediated hemolytic anemia.
Created: 9 Mar 2017, 10:47 a.m.
Created: 9 Mar 2017, 10:47 a.m.

Panel version: 0.458

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Hemolytic anemia, CD59-mediated, with or without immune-mediated polyneuropathy, 612300
OMIM
107271
Clinvar variants
Variants in CD59
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

11 Mar 2017, Gel status: 4

panel promoted to version 1

Arianna Tucci (Genomics England Curator)

Promoted to V1 on 11 March 2017, after internal review and discussion with the clinical team.

9 Mar 2017, Gel status: 4

Gene classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

This gene has been classified as Green List (High Evidence).

9 Mar 2017, Gel status: 4

Set Mode of Inheritance

Rebecca Foulger (Genomics England curator)

Mode of inheritance for CD59 was changed to BIALLELIC, autosomal or pseudoautosomal

9 Mar 2017, Gel status: 4

Set publications

Rebecca Foulger (Genomics England curator)

Publications for CD59 were set to 24382084; 23149847; 1382994

9 Mar 2017, Gel status: 4

Gene classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

This gene has been classified as Green List (High Evidence).

17 Feb 2017, Gel status: 0

Created

Louise Daugherty (Genomics England Curator)

CD59 was created by LouiseD

17 Feb 2017, Gel status: 1

Added New Source

Louise Daugherty (Genomics England Curator)

CD59 was added to Cytopaenias and congenital anaemiaspanel. Sources: Radboud University Medical Center, Nijmegen