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Cytopenias and congenital anaemias

Gene: WT1

Red List (low evidence)

WT1 (Wilms tumor 1)
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 21 panels

2 reviews

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Somatic variants responsible for acute myeloid leukaemia (20368469, 27252512, 8630376). Germline and somatic variants associated with other phenotypes (see comments), not relevant to this panel
Created: 9 Mar 2017, 1:39 p.m.
Comment on phenotypes: Germline and somatic variants also associated with: Denys-Drash syndrome 194080 SMu, AD; Frasier syndrome 136680 SMu, AD; Meacham syndrome 608978; Mesothelioma, somatic 156240; Nephrotic syndrome, type 4 256370 AD; Wilms tumor, type 1 194070 SMu, AD
Created: 9 Mar 2017, 1:39 p.m.

BRIDGE consortium (NIHRBR-RD)

Green List (high evidence)

Mode of inheritance
Unknown

Phenotypes
Acute myeloid leukaemia (AML)

Publications

Variants in this GENE are reported as part of current diagnostic practice

History Filter Activity

11 Mar 2017, Gel status: 1

panel promoted to version 1

Arianna Tucci (Genomics England Curator)

Promoted to V1 on 11 March 2017, after internal review and discussion with the clinical team.

9 Mar 2017, Gel status: 1

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

9 Mar 2017, Gel status: 0

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for WT1 were set to Acute myeloid leukaemia (AML)

9 Mar 2017, Gel status: 0

Set publications

Sarah Leigh (Genomics England Curator)

Publications for WT1 were set to 20368469; 27252512; 8630376

17 Feb 2017, Gel status: 0

Added New Source

Louise Daugherty (Genomics England Curator)

WT1 was added to Cytopaenias and congenital anaemiaspanel. Sources: BRIDGE consortium (NIHRBR-RD)

17 Feb 2017, Gel status: 0

Created

Louise Daugherty (Genomics England Curator)

WT1 was created by LouiseD