FLNA

filamin A
OMIM: 300017, Gene2Phenotype

26 panels

Panel Reviews Mode of inheritance Details
26 panels
Green FLNA in Radial dysplasia

Level 3: Dysmorphic disorders
Level 2: Dysmorphic and congenital abnormality syndromes
Version 1.25

review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
Sources
  • Expert Review Green
  • Other
Phenotypes
  • Frontometaphyseal dysplasia 1, OMIM:305620
  • Melnick-Needles syndrome, OMIM:309350
  • Otopalatodigital syndrome, type I, OMIM:311300
  • Otopalatodigital syndrome, type II, OMIM:304120
  • Terminal osseous dysplasia, OMIM:300244
Red FLNA in Familial Meniere Disease

Level 3: Other hearing and ear disorders
Level 2: Hearing and ear disorders
Version 1.4

review Not set
Sources
  • Literature
Red FLNA in COVID-19 research


Level 2: Viral research
Version 1.146

review Unknown
Sources
  • Literature
Green FLNA in Gastrointestinal neuromuscular disorders

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.30

review X-LINKED: hemizygous mutation in males, biallelic mutations in females
Sources
  • Expert Review Green
  • Radboud University Medical Center, Nijmegen
  • UKGTN
Phenotypes
  • Congenital short bowel syndrome, OMIM:300048
  • Intestinal pseudoobstruction, neuronal, OMIM:300048
Amber FLNA in Hydrocephalus


Level 2: Neurology
Version 5.8
Latest signed off version: v5.0 (7 Aug 2024)

review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
Sources
  • NHS GMS
  • Expert Review Amber
  • Literature
Phenotypes
  • Otopalatodigital syndrome, type II, OMIM:304120
Green FLNA in Limb disorders


Level 2: Musculoskeletal
Version 7.20
Latest signed off version: v7.0 (30 Apr 2025)

Component of the following Super Panels:

  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • London South East RGC GSTT
    • Viapath
    Phenotypes
    • Frontometaphyseal dysplasia 1, OMIM:305620
    • Melnick-Needles syndrome, OMIM:309350
    • Otopalatodigital syndrome, type I, OMIM:311300
    • Otopalatodigital syndrome, type II, OMIM:304120
    • Terminal osseous dysplasia, OMIM:300244
    Green FLNA in Intestinal failure or congenital diarrhoea


    Level 2: Gastrohepatology
    Version 3.7
    Latest signed off version: v3.0 (22 Mar 2023)

    review X-LINKED: hemizygous mutation in males, biallelic mutations in females
    Sources
    • Expert Review Green
    • Literature
    Phenotypes
    • Congenital short bowel syndrome, OMIM:300048
    • Intestinal pseudoobstruction, neuronal, OMIM:300048
    • ?FG syndrome 2, OMIM:300321
    Amber FLNA in Pigmentary skin disorders


    Level 2: Dermatology
    Version 4.13
    Latest signed off version: v4.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Amber
    • London North GLH
    • NHS GMS
    Phenotypes
    • Terminal osseous dysplasia, OMIM:300244
    Green FLNA in Inherited bleeding disorders

    Level 3: Haemostasis disorders
    Level 2: Haematological and immunological disorders
    Version 1.182

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • BRIDGE Study Tier 1 Gene
    Phenotypes
    • Heterotopia, periventricular, 1, OMIM:300049
    • Macrothrombocytopenia
    Green FLNA in Malformations of cortical development


    Level 2: Neurology
    Version 7.30
    Latest signed off version: v7.0 (30 Oct 2024)

    Component of the following Super Panels:

  • Cerebral malformation
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • Radboud University Medical Center, Nijmegen
    • UKGTN
    Phenotypes
    • Heterotopia, periventricular, 1, OMIM:300049
    Tags
    • x-linked-over-dominance
    Green FLNA in Familial non syndromic congenital heart disease

    Level 3: Congenital heart disease
    Level 2: Cardiovascular disorders
    Version 1.90

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • UKGTN
    • Radboud University Medical Center, Nijmegen
    • Literature
    Phenotypes
    • Cardiac valvular dysplasia, X-linked, OMIM:314400
    Green FLNA in Thoracic aortic aneurysm or dissection (GMS)


    Level 2: Cardiology
    Version 4.5
    Latest signed off version: v4.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • South West GLH
    • London South GLH
    • South West GLH
    • London South GLH
    Phenotypes
    • Cardiac valvular dysplasia, X-linked, OMIM:314400
    • Heterotopia, periventricular, 1, OMIM:300049
    Green FLNA in Thoracic aortic aneurysm or dissection

    Level 3: Connective tissue disorders and aortopathies
    Level 2: Cardiovascular disorders
    Version 1.129

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • South West GLH
    • London South GLH
    • Expert Review Green
    • Expert list
    • Emory Genetics Laboratory
    Phenotypes
    • Cardiac valvular dysplasia, X-linked, OMIM:314400
    • Heterotopia, periventricular, 1, OMIM:300049
    Green FLNA in Arthrogryposis


    Level 2: Neurology
    Version 9.24
    Latest signed off version: v9.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • Frontometaphyseal dysplasia 1, OMIM:305620
    • Otopalatodigital syndrome, type I, OMIM:311300
    • Otopalatodigital syndrome, type II, OMIM:304120
    • Terminal osseous dysplasia, OMIM:300244
    Green FLNA in Skeletal dysplasia


    Level 2: Musculoskeletal
    Version 8.34
    Latest signed off version: v8.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • Frontometaphyseal dysplasia 1, OMIM:305620
    • Melnick-Needles syndrome, OMIM:309350
    • Otopalatodigital syndrome, type I, OMIM:311300
    • Otopalatodigital syndrome, type II, OMIM:304120
    • Terminal osseous dysplasia, OMIM:300244
    Green FLNA in Bleeding and platelet disorders


    Level 2: Haematology
    Version 4.6
    Latest signed off version: v4.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • North West GLH
    • Yorkshire and North East GLH
    • London South GLH
    • NHS GMS
    • Wessex and West Midlands GLH
    Phenotypes
    • Heterotopia, periventricular, 1, OMIM:300049
    • Macrothrombocytopenia
    Red FLNA in Cytopenia - NOT Fanconi anaemia


    Level 2: Haematology
    Version 4.32
    Latest signed off version: v4.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Red
    • Expert review Red
    • NHS GMS
    • North West GLH
    • London South GLH
    • Yorkshire and North East GLH
    • Wessex and West Midlands GLH
    Phenotypes
    • Heterotopia, periventricular, 1, OMIM:300049
    • Macrothrombocytopenia
    Amber FLNA in Ehlers Danlos syndrome with a likely monogenic cause


    Level 2: Musculoskeletal
    Version 4.6
    Latest signed off version: v4.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Amber
    • Emory Genetics Laboratory
    • Expert list
    Phenotypes
    • Cardiac valvular dysplasia, X-linked, OMIM:314400
    • Heterotopia, periventricular, 1, OMIM:300049
    Tags
    • Q1_26_promote_green
    • Q1_26_NHS_review
    Green FLNA in Fetal anomalies


    Level 2: Fetal (including NIPD)
    Version 6.140
    Latest signed off version: v6.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • PAGE DD-Gene2Phenotype
    • Expert Review Green
    Phenotypes
    • TERMINAL OSSEOUS DYSPLASIA
    • OTOPALATODIGITAL SYNDROME TYPE 1
    • EPILEPTIC ENCEPHALOPATHY
    • MELNICK-NEEDLES SYNDROME
    • PERIVENTRICULAR NODULAR HETEROTOPIA TYPE 1
    • FG SYNDROME TYPE 2
    • X-LINKED CONGENITAL IDIOPATHIC INTESTINAL PSEUDOOBSTRUCTION
    • OTOPALATODIGITAL SYNDROME TYPE 2
    • FRONTOMETAPHYSEAL DYSPLASIA
    Green FLNA in Rare syndromic craniosynostosis or isolated multisuture synostosis


    Level 2: Musculoskeletal
    Version 6.3
    Latest signed off version: v6.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • NHS GMS
    • Expert Review Green
    • Expert list
    Phenotypes
    • Frontometaphyseal dysplasia 1, OMIM:305620
    • Melnick-Needles syndrome, OMIM:309350
    • Otopalatodigital syndrome, type I, OMIM:311300
    • Otopalatodigital syndrome, type II, OMIM:304120
    No list FLNA in Osteogenesis imperfecta


    Level 2: Musculoskeletal
    Version 5.4
    Latest signed off version: v5.0 (30 Apr 2025)

    review Not set
    Sources
    • Expert Review Removed
    • Emory Genetics Laboratory
    Phenotypes
    • Disproportionate Short Stature
    Tags
    • curated_removed
    Green FLNA in DDG2P


    Version 6.424
    Latest signed off version: v6.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • DD-Gene2Phenotype
    • Expert Review Green
    Phenotypes
    • PERIVENTRICULAR NODULAR HETEROTOPIA 1 300049
    • FRONTOMETAPHYSEAL DYSPLASIA 305620
    • FG SYNDROME TYPE 2 300321
    • X-LINKED CONGENITAL IDIOPATHIC INTESTINAL PSEUDOOBSTRUCTION 300048
    • MELNICK-NEEDLES SYNDROME 309350
    • Childhood Interstitial Lung Disease
    • EPILEPTIC ENCEPHALOPATHY
    • OTOPALATODIGITAL SYNDROME TYPE 1 311300
    • OTOPALATODIGITAL SYNDROME TYPE 2 304120
    • TERMINAL OSSEOUS DYSPLASIA 300244
    Tags
    • mosaicism
    Green FLNA in Clefting


    Level 2: Musculoskeletal
    Version 6.20
    Latest signed off version: v6.5 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • Expert Review Green
    • UKGTN
    Phenotypes
    • Frontometaphyseal dysplasia 1, OMIM:305620
    • Melnick-Needles syndrome, OMIM:309350
    • Otopalatodigital syndrome, type I, OMIM:311300
    • Otopalatodigital syndrome, type II, OMIM:304120
    Green FLNA in Early onset or syndromic epilepsy


    Level 2: Neurology
    Version 8.125
    Latest signed off version: v8.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Paediatric disorders
  • Unexplained death in infancy and sudden unexplained death in childhood
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • North West GLH
    • Expert Review Green
    • Wessex and West Midlands GLH
    • NHS GMS
    • Victorian Clinical Genetics Services
    Phenotypes
    • Heterotopia, periventricular OMIM:300049
    Red FLNA in Intellectual disability


    Level 2: Developmental disorders
    Version 9.285
    Latest signed off version: v9.0 (30 Apr 2025)

    Component of the following Super Panels:

  • Childhood onset leukodystrophy
  • Hypotonic infant
  • Paediatric disorders
  • review X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
    Sources
    • NHS GMS
    • Expert Review Red
    • Victorian Clinical Genetics Services
    • Radboud University Medical Center, Nijmegen
    • Emory Genetics Laboratory
    Phenotypes
    • Heterotopia, periventricular, 1, OMIM:300049
    • Otopalatodigital syndrome, type II, OMIM:304120
    • ?FG syndrome 2, OMIM:300321
    Green FLNA in Paediatric pseudo-obstruction syndrome


    Level 2: Gastrohepatology
    Version 2.5
    Latest signed off version: v2.0 (30 Apr 2025)

    review X-LINKED: hemizygous mutation in males, biallelic mutations in females
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • Congenital short bowel syndrome, OMIM:300048
    • Intestinal pseudoobstruction, neuronal, OMIM:300048