HEY2

hes related family bHLH transcription factor with YRPW motif 2
OMIM: 604674, Gene2Phenotype

2 panels

Panel Reviews Mode of inheritance Details
2 panels
Red HEY2 in Thoracic aortic aneurysm or dissection (GMS)


Level 2: Cardiology
Version 4.5
Latest signed off version: v4.0 (30 Apr 2025)

review BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • Literature
Phenotypes
  • congenital heart defects, multiple type, MONDO:0000119
  • thoracic aortic aneurysm, MONDO:0005396
Amber HEY2 in Fetal anomalies


Level 2: Fetal (including NIPD)
Version 6.184
Latest signed off version: v6.0 (30 Apr 2025)

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
Phenotypes
  • Tetralogy of Fallot