ICOS

inducible T-cell costimulator
OMIM: 604558, Gene2Phenotype

6 panels

Panel Reviews Mode of inheritance Details
6 panels
Green ICOS in Infantile enterocolitis & monogenic inflammatory bowel disease

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.42

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Emory Genetics Laboratory
  • UKGTN
  • Radboud University Medical Center, Nijmegen
  • Illumina TruGenome Clinical Sequencing Services
  • Expert list
Phenotypes
  • Immunodeficiency, common variable, 1 607594
Green ICOS in Gastrointestinal epithelial barrier disorders

Level 3: Gastrointestinal disorders
Level 2: Gastroenterological disorders
Version 1.74

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Emory Genetics Laboratory
Phenotypes
  • Early Onset Inflammatory Bowel Disease
  • Immunodeficiency, common variable, 1 607594
Green ICOS in COVID-19 research


Level 2: Viral research
Version 1.141

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • IUIS Classification February 2018
  • A- or hypo-gammaglobulinaemia v1.25
  • London North GLH
  • GOSH PID v.8.0
  • NHS GMS
  • GRID V2.0
  • Victorian Clinical Genetics Services
  • North West GLH
  • ESID Registry 20171117
  • Expert Review Green
  • NHS GMS
  • North West GLH
  • London North GLH
  • Expert Review Green
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • ESID Registry 20171117
  • GRID V2.0
  • GOSH PID v.8.0
  • A- or hypo-gammaglobulinaemia v1.25
Phenotypes
  • combined immunodeficiency
  • Isolated IgG subclass deficiency
  • gammaglobulinaemia
  • Immunodeficiency, common variable, 1, 607594
  • Immunodeficiencies affecting cellular and humoral immunity
  • Common variable immunodeficiency disorders (CVID)
  • hypogammaglobulinaemia
  • Immunodeficiency, common variable, 1
  • Recurrent infections, autoimmunity, gastroenteritis, granulomas
Green ICOS in Intestinal failure or congenital diarrhoea


Version 3.3
Latest signed off version: v3.0 (22 Mar 2023)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Immunodeficiency, common variable, 1, OMIM:607594
Green ICOS in Primary immunodeficiency or monogenic inflammatory bowel disease


Version 4.191
Latest signed off version: v4.0 (22 Mar 2023)

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Other
  • NHS GMS
  • North West GLH
  • London North GLH
  • IUIS Classification February 2018
  • Victorian Clinical Genetics Services
  • ESID Registry 20171117
  • GRID V2.0
  • GOSH PID v.8.0
  • A- or hypo-gammaglobulinaemia v1.25
Phenotypes
  • Immunodeficiency, common variable, 1
  • Immunodeficiency, common variable, 1, 607594
  • Common variable immunodeficiency disorders (CVID)
  • Isolated IgG subclass deficiency
  • hypogammaglobulinaemia
  • gammaglobulinaemia
  • combined immunodeficiency
  • Recurrent infections, autoimmunity, gastroenteritis, granulomas
  • Immunodeficiencies affecting cellular and humoral immunity
Tags
  • deletions
Green ICOS in Severe Paediatric Disorders


Version 1.182

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Next Generation Children Project
  • Expert Review Green
  • Expert list
Phenotypes
  • Immunodeficiency, common variable, 1, 607594