Gastrointestinal epithelial barrier disorders
Gene: ICOSComment on list classification: Expert review and previous curation have noted cases presenting with gastrointestinal disorder phenotypes (diarrhea and recurrent enteritis) with variants in this gene as part of Common Variable Immunodeficiency 1. Therefore, this gene will be promoted to green.Created: 26 Jul 2018, 11:34 a.m.
Associated with phenotype in OMIM, not in G2P / DD. Present on UKGTN Very Early Onset Inflammatory Bowel Disease 40 Gene Panel and Emory Genetics Laboratory Early Onset Inflammatory Bowel Disease: Sequencing Panel. Four homozygous variants reportedCreated: 5 Sep 2016, 6:51 a.m.
Gene: icos has been classified as Green List (High Evidence).
Panel reviews have been assessed and internal clinical team opinion has been sought on this panel, particularly to rule out incidental findings. Panel has been revised through expert review, internal review and literature research. 25/07/2018
Model of inheritance for gene ICOS was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene ICOS were set to Early Onset Inflammatory Bowel Disease, Immunodeficiency, common variable, 1 607594 Publications for gene ICOS was set to ['26399252', ' 19380800', ' 25678089', ' 12577056']
ICOS was added to Gastrointestinal epithelial barrier disorders panel. Sources: Emory Genetics Laboratory
ICOS was created by Olivia Niblock